Sponsor or institution
Clinical trials and research at University of Massachusetts Amherst
As of November 12, 2026, Find a Trial lists 4 clinical trials run by University of Massachusetts Amherst that are recruiting, in United States. By phase: Early Phase 1 (1). There are also 218 NIH-funded research projects at this institution, with $104.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 218NIH research projects
- 1Country
Newest trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Oral cooling spray to relieve burning mouth symptoms | Early Phase 1 | Amherst, Massachusetts | Recruiting | Jun 11, 2025 |
| Aphasia ID cards to help service workers understand people with aphasia | — | Springfield, Massachusetts | Recruiting | May 25, 2025 |
| Investigating the Role of Naps in Infant Memory Development | — | Amherst, Massachusetts | Recruiting | May 6, 2024 |
| Understanding how sleep affects memory in older adults | — | Amherst, Massachusetts | Recruiting | Feb 15, 2019 |
All recruiting trials (4)
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Oral cooling spray to relieve burning mouth symptoms
Over two weeks, adults with burning mouth syndrome will try an over-the-counter oral cooling spray (Dr.B's Elixir) to see if it reduces burning, decreases symptom frequency, and improves eating enjoyment.
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Aphasia ID cards to help service workers understand people with aphasia
This project will test whether showing service workers an aphasia identification card helps them better understand people with aphasia.
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Investigating the Role of Naps in Infant Memory Development
This study is testing how taking naps affects memory development in babies aged 9 to 15 months.
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Understanding how sleep affects memory in older adults
This study is testing how sleep affects memory in older adults to see if better sleep can help them remember things more effectively.
NIH-funded research (newest 40 of 218)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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New England Center of Excellence in Vector-Borne Diseases (NEWVEC)
A center in New England will develop and test practical ways to prevent tick bites and reduce diseases from ticks, while training public health workers and engaging communities.
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Understanding how minority stress affects cannabis use in sexual minorities
A research project follows young adult sexual minorities to see how daily stress and coping help explain cannabis use and related problems.
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A non-contact way to measure stiffness in hydrogel scaffolds for tissue engineering
A new method uses 2D acoustic force elastography microscopy to measure how stiff hydrogel scaffolds are, without touching them, to help tissue engineering efforts.
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Automated neural identification across species and development
A computer-driven project to map and track every neuron in molluscs’ brains as they grow and evolve, to better understand how brains stay organized over time.
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Nanopore Tweezers to Study Kinase Movements and Find Allosteric Inhibitors in Cancers
A new technology uses nanopore tweezers to watch how cancer-related kinases move in real time and to screen for drugs that stop them by binding at sites away from the active site.
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Promesa: Urban gardens and peer nutrition to help people with HIV in the Dominican Republic
A unified program uses urban gardening and peer nutrition counseling to help people living with HIV who are food insecure in the Dominican Republic improve their health and HIV outcomes.
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New England Center of Excellence in Vector-Borne Diseases (NEWVEC)
A regional center in New England will develop better ways to protect people from ticks and other disease-carrying insects, train public health entomologists, and involve communities to reduce tick bites and Lyme disease.
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Promesa: Urban gardens and peer nutrition support for people with HIV in the Dominican Republic
This project offers urban gardening and peer-led nutrition support to people living with HIV who face food insecurity in the Dominican Republic to help keep their viral load undetectable and stay on treatment.
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At-home HIV fingerprick test that finds tiny amounts of the p24 protein
This project is building a fingerprick at-home HIV test that uses nanopore sensing to detect very small amounts of the p24 protein so infections can be caught earlier.
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Cold-triggered numbing for on-demand pain relief
An injectable that stays inactive until the area is cooled, releasing a tiny amount of a powerful numbing drug to give on-demand local pain relief.
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Multi-directed super-adjuvant cancer vaccine Nano-therapy
A new cancer vaccine approach using tiny nanoparticles that carry two powerful adjuvants to boost the immune system’s attack on tumors.
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How Spatial Hearing Helps Us Listen Better in Noise as We Age
This project looks at how the brain uses space to separate sounds and helps people hear in noisy places, especially as we get older.
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Age-related changes in how brain rhythms during sleep affect memory in older adults
This research looks at how sleep-related brain waves in healthy older adults relate to memory, with a focus on how aging might disrupt this process and contribute to Alzheimer’s-related dementia.
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Preconception exposure to everyday chemicals and healthy pregnancy outcomes
A preconception study will look at how common chemicals in the environment and some metals may affect a couple’s chances of getting pregnant and carrying a healthy baby.
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Synthetic biology core for creating helpful bacteria to fight tumors
A team at UMASS Amherst is building engineered bacteria to better target and attack tumors and deliver cancer-fighting payloads.
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Theranostic treatment for breast cancer using bacteria-guided radioactive therapy
A new approach uses engineered bacteria to help deliver targeted radioactive therapy to breast tumors, potentially benefiting people with aggressive forms like triple-negative breast cancer.
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Bacterial delivery of cancer-killing viruses to fight solid tumors
Aims to use a friendly bacterial carrier to bring oncolytic viruses directly to tumors to help treat cancers, including breast metastases.
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Bacterial immunotherapy to boost anti-tumor immunity in breast cancer
A new approach uses engineered Salmonella to deliver cancer antigens inside tumor cells to wake up memory immune cells and help fight breast cancer, especially tough-to-treat triple-negative tumors.
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Administrative Core for Microbial Therapies Program Project
A coordinated program to develop microbial therapies that help people with triple-negative breast cancer who don’t respond to current immunotherapies.
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Microbial therapies to fight triple-negative breast cancer
A program aims to create engineered microbes that deliver cancer-fighting therapies directly to TNBC tumors to provoke lasting immune responses.
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Nanopore Tweezers to Map Kinase Movements and Find Allosteric Drugs
A new nanopore-based tool will watch how disease-related kinases change shape in real time to help identify allosteric drugs.
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MassJCOIN II Clinical Research Hub: Improving Transitional Care for Opioid Use Disorder in Jail to Community
A national-scale research hub will study how new Medicaid rules before jail release can help people with opioid use disorder stay on treatment after they leave custody.
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Point-of-care liver disease test with fluorescent nanosensors
A lightweight, easy test that uses fluorescent sensors on paper to detect liver fibrosis and cirrhosis at the point of care.
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Cardiovascular Risk in at-risk Hispanic women after pregnancy complications
We’re studying how pregnancy challenges in Hispanic women relate to heart and mental health later in life, to help identify who’s at higher risk and what care they might need.
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Cell control with tiny, fast pH changes around cells
A new approach uses nanoelectrochemistry and graphene microelectrodes to precisely alter pH around cells in real time, potentially guiding cell behavior for therapies.
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Why walking costs more energy as we age and how to fix it
As we get older, walking can take more energy, and this study aims to understand why so energy is wasted and how to reduce it.
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Proteins that form amyloid and how to stop them using mass spectrometry
Researchers will use advanced mass spectrometry to understand how amyloid proteins begin to form and to find compounds that stop this process, with a focus on diseases like Alzheimer's and dialysis-related amyloidosis.
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Understanding how tissue environments shape disease with single-cell spatial data
A researcher at UMass Amherst is using advanced single-cell spatial data and mathematical models to uncover how tissue environments influence autoimmune diseases and cancer.
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Understanding how RNA-protein condensates work in living cells and what goes wrong in cancer
A scientist at a university will study tiny RNA-protein assemblies inside living cells to learn how they form, stay intact, and contribute to cancer and other diseases.
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Biophysics and cell biology of meso-scale gap closure
A research project at a major university will study how tissues close gaps during wound healing and development, using engineered meso-scale gaps to understand the physics and biology of tissue movement.
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How the calcium-sensing protein CaMKII shapes heart, brain, and egg cell function
This project explains how different forms of the calcium-sensing protein CaMKII work in heart cells, brain cells, and egg cells to support heartbeat, memory, and fertilization.
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Demineralized bone paper models to study human bone aging and senolytic drugs
Aims to create easy-to-use human bone models on paper-like sheets to study aging and drugs that target aging cells, which could help prevent bone metastasis in cancer survivors.
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How cells fold proteins and handle misfolding
This research looks at how cells use helper proteins called Hsp70 to fold other proteins properly and prevent the kind of misfolding that can lead to Alzheimer's.
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Peroxisome quality control and cellular health
A funded project at a university investigates how peroxisomes stay healthy inside cells and what happens when their quality control fails, with the goal of supporting future scientists and improving biology knowledge.
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Short intense exercise breaks to interrupt long sitting and boost older adults' brain health
This project will try brief high-intensity exercise breaks during long periods of sitting to help attention and memory in older adults.
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How babies sleep: understanding naps and memory in infancy
This study follows 100 infants over their first year to see how napping patterns affect early memory and brain development.
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How the lungs' first responders react to TB bacteria
Aimed at understanding how alveolar macrophages in the lungs respond to TB bacteria to help create better vaccines and therapies.
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PolyTACs: a new way to remove harmful membrane proteins from cells
A new polymer-based system called PolyTACs aims to selectively remove membrane proteins from cells, potentially improving treatments by eliminating problematic proteins rather than just blocking them.
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Cold-triggered Local Anesthesia for Pain Relief
A study testing a cold-triggered local anesthetic system designed to release pain-relief medicine when and where it’s needed, to help patients manage pain more effectively.
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CaMKII in Mammalian Egg Activation: Real-time Biosensors to Predict Fertility Reproduction Outcomes
Aims to watch how CaMKII activity changes in egg cells during maturation and fertilization using new real-time biosensors to better understand early embryo development.
Quick answers
How many clinical trials run by University of Massachusetts Amherst are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.