Peroxisome quality control and cellular health
Official title: Peroxisomal quality control mechanisms
Funded at University of Massachusetts Amherst · NIH-11372256 · Data updated 2026-11-12
A funded project at a university investigates how peroxisomes stay healthy inside cells and what happens when their quality control fails, with the goal of supporting future scientists and improving biology knowledge.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | July 10, 2025 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00GM146026-04 |
| Project ID | NIH-11372256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient recruitment; focuses on basic cellular biology and training of a future professor.
✕Less likely to help
Direct patient benefits are not the immediate focus of this grant.
What this research studies
This project looks at how peroxisomes, tiny cellular organs, are kept in good shape by quality-control systems and what goes wrong when this process breaks down. The researcher is training across proteomics, biochemistry, and cell biology to build a strong, independent career in academia. The work will use advanced lab methods at Rice University and collaborating Texas Medical Center institutions. The aim is to uncover how peroxisomal signals influence autophagy and cellular health, with broader implications for understanding disease-related cellular stress. The environment emphasizes interdisciplinary training, mentorship, and preparing the next generation of scientists.
Why it matters
Potential benefit: Understanding peroxisomal quality control could lead to new insights into cellular health and disease, potentially guiding future therapies.
How similar studies have gone: Previous work has shown peroxisome turnover via autophagy, suggesting this line of inquiry could yield meaningful advances.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Muhammad, Durreshahwar — University of Massachusetts Amherst
- Study coordinator: Muhammad, Durreshahwar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.