Sponsor or institution

Clinical trials and research at University of Connecticut Sch of Med/dnt

• 274NIH research projects

NIH-funded research (newest 40 of 274)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mapping the full range of human genome structure variations

  Researchers are building better maps of the big and small differences in human DNA to improve precision medicine.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11627257

• Understanding the full spectrum of structural genetic variation in human genomes

  Scientists are improving how we detect complex DNA changes across many human genomes to advance precision medicine.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11627138

• Mapping all kinds of genetic differences in human genomes to improve precision medicine

  A national researchers team is creating better ways to find and understand big genetic differences in human DNA to help doctors tailor care.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11627084

• Total Worker Health program for safer, healthier workplaces

  A large, multi-year program aims to improve worker health and safety by addressing the whole work environment for people in real-world jobs.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11623432

• Nfe2l3 helps retinal cells heal and may restore simple vision after optic nerve injuries

  A scientist at a major university studies how a protein called Nfe2l3 could help retinal nerve cells regrow their axons and potentially restore basic vision after optic nerve injuries.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11605915

• Nfe2l3-driven protection and optic nerve repair for vision

  This grant explores how a protein called Nfe2l3 might help retinal nerve cells repair damaged optic nerves to restore simple vision after injuries.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11605863

• Mapping the full spectrum of human genetic variation to improve precision medicine

  A large-scale effort to map complex structural genetic differences across diverse populations to help doctors better understand how genomes contribute to autism and other conditions.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11586136

• Molecular mechanisms of Shiga toxin–induced cell death in children

  This grant looks at how Shiga toxin damages cells and causes disease, with a focus on late-stage cell death processes that could affect kids.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11572341

• Computational tools to boost biomolecular NMR for disease research

  A grant to build and share computer tools that make biomolecular NMR easier to use for studying diseases and related biomolecules.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11529082

• Low-cost CRISPR-on-Paper Cervical Cancer Screening at the Point of Care

  A new, inexpensive paper-based CRISPR test aims to quickly screen women for high-risk HPV genotypes right where they receive care, especially in low-resource settings.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11524815

• Low-cost paper CRISPR test for cervical cancer screening

  A cheap, paper-based CRISPR test is being developed to quickly find high-risk HPV types for women, especially in low-resource clinics.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11517886

• Understanding how cerebellar hemispheres form and shape thinking and movement

  A research project at the University of Connecticut aims to understand how the cerebellar hemispheres develop and organize, which can affect movement, attention, language, and learning.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11456216

• Bioengineered probiotic to curb binge drinking

  A new probiotic therapy is being developed to produce a gut metabolite that helps reduce binge drinking in people by delivering it continuously in the gut.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11448028

• Tau, enzymes, and Alzheimer’s disease: how tau phosphorylation is controlled

  A patient-friendly look at a study trying to understand why tau builds up in Alzheimer’s and how brain enzymes that add or remove phosphate groups might influence disease.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11447025

• Inducible gene dosage correction in Down Syndrome organoid and rodent models carrying human chromosome 21

  A study explores turning down extra chromosome 21 genes in lab-grown brain organoids and animal models to see if it can prevent or lessen Down syndrome–related brain changes.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11442340

• Understanding how to predict and prevent pregnancy complications related to placental invasion

  Researchers will study how signaling between maternal tissues and invading placental cells affects pregnancy health, with the goal of predicting and reducing disorders like preeclampsia and growth problems.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11415751

• Peers and group motivational interviewing in emerging adults and the brain

  A new approach tests how peer influence in group sessions affects brain and behavior in 18–19 year-olds who drink alcohol.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11415087

• Deciphering Borrelia burgdorferi gene switches in ticks and people

  This grant studies how the Lyme disease bacterium changes its gene activity when it moves between ticks and mammals, aiming to better understand how infection happens.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11403975

• Skeletal bone data sharing for rodent studies

  Aiming to create a public data repository that collects and shares bone-phenotyping data from mouse studies to help researchers understand skeletal biology and related human diseases.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11403965

• How uterine and placental cells communicate to affect placental invasion

  Using computational genetics, researchers aim to link signals in uterine cells to risks of pregnancy problems like preeclampsia, fetal growth restriction, and placenta previa for pregnant people.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11400336

• Collaborative Hub for Emerging Adult Recovery Research (CHEARR)

  A national research hub is being created to better understand and improve long-term recovery for 16- to 25-year-olds with opioid use disorder, focusing on ongoing support after starting medications for OUD.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11399017

• Cleaner air at home for families: making affordable air purifiers work for you

  This project tests low-cost Corsi-Rosenthal boxes to reduce indoor air pollution for people, including families in underserved communities, with the goal of lowering health risks from dirty air.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11397681

• AAV-based therapy to help TNNT2-related heart disease

  A new gene-delivery approach using adeno-associated viruses (AAVs) aims to restore healthy TNNT2 function in people with certain inherited heart muscle diseases.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11396543

• Computational tools to boost biomolecular NMR for disease research

  A research project will create and improve computer tools that help scientists use biomolecular NMR to study diseases.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11392527

• Regulation of a key brain enzyme linked to Parkinson’s and related dementias

  This grant aims to understand how improving the folding and movement of the enzyme GCase in brain cells could help people with Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11388896

• How X and Y chromosomes shape health from early development

  Scientists are studying how the X and Y chromosomes influence pregnancy and health, especially when there is only one copy of a chromosome or when certain X-linked genes escape inactivation.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11387647

• Perinuclear RyR2 and heart cell signaling network in hypertrophy

  A heart researcher is exploring how specialized calcium signals near the cell nucleus control harmful heart muscle growth, with the goal of finding new therapies.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11385428

• How RNA modifications and structures control early embryo development

  A study in zebrafish and other models will explore how chemical marks on maternal RNAs and their 3D shapes govern the first moments of development after fertilization.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11384482

• Mechanistic Modeling Tools for Cellular Biology

  A national resource continues to provide powerful 3D cell modeling tools to researchers, helping scientists simulate how cells work.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11384320

• CRISPR-based HIV viral load test that works at the point of care

  A new, fast, affordable HIV viral load test using CRISPR signals designed to work outside centralized labs for people living with HIV or at risk.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11378757

• Inhibiting BACE1 to Help Alzheimer’s Patients

  A scientist team is testing a new approach to slow Alzheimer’s by safely blocking BACE1, an enzyme involved in clear Alzheimer’s plaques, with potential benefit for people with the condition.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11377615

• Linkages between HIV prevention and risky behaviors in high-risk youth

  A study with youth ages 13-24 explores how HIV/STI prevention programs relate to other risk behaviors to find common factors and unique pathways.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11376000

• Calcium signaling and TRPM7 in heart scarring (cardiac fibrosis)

  A heart-disease project explores how calcium signaling in heart fibroblasts drives fibrosis and tests if blocking TRPM7 could prevent scarring.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11375970

• Helping people with dementia move back home through the Money Follows the Person program

  This grant studies why older adults with Alzheimer's and related dementias have trouble returning home from nursing facilities and how to improve their chances with better program access and support.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11372988

• Understanding the causes of craniometaphyseal dysplasia (CMD) to guide better treatments

  This project studies why CMD, a rare bone disorder, happens at the cellular and molecular level with the goal of improving therapies for affected individuals.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11372077

• NOTCH2's role in joint inflammation

  This work looks at how changes in the NOTCH2 gene make joint cells more inflamed and may contribute to osteoarthritis in people with joint degeneration.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11370319

• Cap-linker approach to direct oncolytic virus therapy to bladder and breast cancers

  A new strategy aims to make oncolytic viruses more likely to reach and kill bladder and breast cancer cells in people who need better treatments.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11367788

• Targeting how IL-17 signaling changes regulatory T cells in colorectal cancer

  This project will study how a specific immune pathway affects regulatory T cells in colorectal cancer to discover ways to block tumor-friendly T cell activity without harming normal immune balance.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11367653

• Depression and Financial Skills in Older Adults

  A study investigating how late-life depression may affect older adults’ ability to manage money and avoid scams, with findings aimed at improving protection and support.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11367503

• Regulation of antibacterial interferon defense by MiT transcription factors

  This grant explores how MiT family proteins (like TFE3 and TFEB) help the body trigger protective interferon responses against bacterial infections such as EHEC.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11367102

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