Understanding how to predict and prevent pregnancy complications related to placental invasion
Official title: Mapping inter-cellular trophoblast-decidual signaling to its effects on invasion related maternal-fetal
Funded at University of Connecticut Sch of Med/dnt · NIH-11415751 · Data updated 2026-11-12
Researchers will study how signaling between maternal tissues and invading placental cells affects pregnancy health, with the goal of predicting and reducing disorders like preeclampsia and growth problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HD105973-05 |
| Project ID | NIH-11415751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals who are pregnant or planning pregnancy and at risk for IMFDs such as preeclampsia or fetal growth restriction.
✕Less likely to help
Patients without IMFD risk factors may see less direct benefit.
What this research studies
This project looks at how gene regulation at the maternal-fetal interface controls how easily the placenta can invade the lining of the uterus. By using machine learning, comparative genomics, and computational prediction of regulatory elements, the team aims to identify key signals that keep endometrial tissue healthy during early pregnancy. They will build models that connect specific transcriptional profiles to the risk of invasion-related pregnancy diseases. The work combines data-driven analysis with mechanistic insights to create a prognostic tool that could inform risk assessment for IMFDs. If successful, the approach could guide future interventions to improve pregnancy outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention of serious pregnancy complications.
How similar studies have gone: Previous research has shown that transcriptional regulation at the maternal-fetal interface relates to invasion and related disorders; this study builds on that by adding predictive modeling.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Suhail, Yasir — University of Connecticut Sch of Med/dnt
- Study coordinator: Suhail, Yasir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.