Mechanistic Modeling Tools for Cellular Biology
Official title: Mechanistic Modeling of Cellular Systems
Funded at University of Connecticut Sch of Med/dnt · NIH-11384320 · Data updated 2026-11-12
A national resource continues to provide powerful 3D cell modeling tools to researchers, helping scientists simulate how cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | August 1, 2020 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,206,574 |
| NIH project number | 5R24GM137787-07 |
| Project ID | NIH-11384320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a direct patient enrollment study; however, patients with conditions connected to cellular dysfunction may indirectly benefit through faster, more informed therapeutic development.
✕Less likely to help
This grant does not involve direct patient participation or clinical testing.
What this research studies
If you’re a patient? This grant keeps COPASI and Virtual Cell available for scientists to model cell behavior in 0D–3D environments, including reactions, diffusion, and membrane processes. By supporting thousands of researchers and hundreds of publications, it helps translate cellular mechanisms into potential therapies and better understanding of aging and disease. The resources enable different simulation approaches, so researchers can test hypotheses more efficiently and with real-world relevance. The grant funds ongoing software maintenance, user support, and community outreach.
Why it matters
Potential benefit: If successful, advances in cellular modeling could accelerate drug discovery and our understanding of diseases at the cellular level.
How similar studies have gone: Copious prior use and thousands of active users show strong value and impact in the field of systems biology.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Mendes, Pedro — University of Connecticut Sch of Med/dnt
- Study coordinator: Mendes, Pedro
Related research
Other NIH-funded projects on the same topics.
-
Mapping the full range of human genome structure variations
Researchers are building better maps of the big and small differences in human DNA to improve precision medicine.
-
Understanding the full spectrum of structural genetic variation in human genomes
Scientists are improving how we detect complex DNA changes across many human genomes to advance precision medicine.
-
Mapping all kinds of genetic differences in human genomes to improve precision medicine
A national researchers team is creating better ways to find and understand big genetic differences in human DNA to help doctors tailor care.
-
Total Worker Health program for safer, healthier workplaces
A large, multi-year program aims to improve worker health and safety by addressing the whole work environment for people in real-world jobs.
-
Nfe2l3 helps retinal cells heal and may restore simple vision after optic nerve injuries
A scientist at a major university studies how a protein called Nfe2l3 could help retinal nerve cells regrow their axons and potentially restore basic vision after optic nerve injuries.
-
Nfe2l3-driven protection and optic nerve repair for vision
This grant explores how a protein called Nfe2l3 might help retinal nerve cells repair damaged optic nerves to restore simple vision after injuries.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.