Sponsor or institution

Clinical trials and research at University of California, Merced

• 40NIH research projects

NIH-funded research (40)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• HOME: Smart, compassionate AI helpers for aging at home

  A research project is developing an AI-powered, multimodal system to help older adults stay safe and healthy at home while supporting busy caregivers.

  NIH research University of California, Merced · Merced, United States · NIH-11579078

• How master 'pioneer' proteins read DNA and shape cell identity

  This project looks at how special 'pioneer' proteins read DNA inside cells to guide development and how those processes relate to cancer and regenerative medicine.

  NIH research University of California, Merced · Merced, United States · NIH-11474543

• Engineering vCCI to change how it binds chemokines

  Researchers will study a viral protein called vCCI that can calm inflammation and explore how to tweak its binding to inflammation signals to potentially help conditions like arthritis and asthma.

  NIH research University of California, Merced · Merced, United States · NIH-11424244

• How stem cells renew tissues and cancer development, using planarians

  A scientist team at UC Merced studies how stem cells renew tissues and how DNA damage can lead to cancer, using a planarian model to understand early changes.

  NIH research University of California, Merced · Merced, United States · NIH-11388616

• Understanding how blood vessels and endothelial cells help the thymus heal after intensive cancer therapy

  This NIH grant explores how blood vessels and their lining cells help the thymus recover after chemotherapy, aiming to support better immune recovery in adults.

  NIH research University of California, Merced · Merced, United States · NIH-11374989

• Understanding how enzyme shapes and movements control their activity

  This grant explores how temperature-driven changes in enzyme shapes affect their activity, with the goal of finding hidden states that could help drug discovery.

  NIH research University of California, Merced · Merced, United States · NIH-11361141

• Wildfire smoke and pregnancy health: protecting moms and babies

  A study from UC Merced will look at how wildfire smoke affects pregnant people and newborns and test practical ways to reduce exposure and health risks.

  NIH research University of California, Merced · Merced, United States · NIH-11347732

• Computational study of RNA polymerase II elongation dynamics in autism-related biology

  A computer-based study will model how RNA polymerase II behaves during gene reading to understand mechanisms that may relate to autism.

  NIH research University of California, Merced · Merced, United States · NIH-11329394

• How genes shape biofilms that grow on body surfaces and medical devices

  This project looks at how genetic programs in bacteria, fungi (like Candida), and archaea build biofilms that can cause infections for people with catheters, implants, or chronic mucosal infections.

  NIH research University of California, Merced · Merced, United States · NIH-11327377

• How local immigrant policies affect rural Latino mental health and access to care

  This project looks at how county immigrant policies, community attitudes, and personal encounters with institutions affect mental health and the ability to get health care for rural Latino adults.

  NIH research University of California, Merced · Merced, United States · NIH-11289350

• How a brain protein complex helps nerve cells form connections and relates to autism

  Researchers are looking at how a brain protein complex called nBAF helps nerve cells turn on genes and form connections, which may be important for children with autism linked to specific gene changes.

  NIH research University of California, Merced · Merced, United States · NIH-11251937

• Why some people may be more susceptible to mild Toxoplasma (toxoplasmosis) infections

  It looks for inherited genetic differences that might make some people more likely to become sick after infection with milder strains of Toxoplasma.

  NIH research University of California, Merced · Merced, United States · NIH-11229613

• Investigating how certain proteins recognize and respond to DNA from pathogens

  This study is looking at how certain proteins in your body recognize and respond to harmful germs, which could help us find new ways to treat autoimmune diseases and cancer by improving how your immune system reacts.

  NIH research University of California, Merced · Merced, United States · NIH-11200534

• How alcohol changes sleep and memory brain circuits

  This project looks at how a single alcohol exposure can alter brain circuits that control sleep and memory to better understand why alcohol can lead to lasting changes and addiction risk for adults who drink.

  NIH research University of California, Merced · Merced, United States · NIH-11179453

• Helping the thymus heal after strong cancer treatments

  This research explores how blood vessels in the thymus help it recover after intensive cancer treatments, like those used before a stem cell transplant.

  NIH research University of California, Merced · Merced, United States · NIH-11162482

• Understanding how proteins change shape to work

  This project explores how tiny shape changes in important proteins, like those involved in many diseases, affect their function, which could help us find new ways to develop medicines.

  NIH research University of California, Merced · Merced, United States · NIH-11128584

• Understanding how new proteins in cilia affect cell signaling in development and disease

  This study is looking at how new proteins in tiny cell structures called cilia help control important signals that affect development and can be linked to birth defects and cancers, aiming to better understand how these proteins work and what it means for health.

  NIH research University of California, Merced · Merced, United States · NIH-11074022

• How certain proteins influence cell behavior and development

  This study is looking at how certain proteins called pioneer transcription factors help decide what type of cells we become during development and how they might play a role in diseases like cancer, focusing on a specific protein in a common fungus.

  NIH research University of California, Merced · Merced, United States · NIH-11066326

• Understanding how the brain remembers alcohol tolerance in fruit flies

  This project explores how the brain creates lasting changes that lead to alcohol tolerance, using fruit flies to uncover new insights.

  NIH research University of California, Merced · Merced, United States · NIH-11063201

• Understanding how certain genes affect susceptibility to a common parasite.

  This study is looking at how genes might affect how sick mice get from a parasite called Toxoplasma gondii, which can also make people ill, to help us understand why some people get sicker than others.

  NIH research University of California, Merced · Merced, United States · NIH-11058006

• Investigating how a specific protein complex affects brain development and autism.

  This study is looking at how a group of proteins called the BAF complex affects brain development and could be linked to autism, with the hope that understanding these connections will help create better treatments for people with autism.

  NIH research University of California, Merced · Merced, United States · NIH-11047359

• Using special cells and materials to improve blood flow in limbs affected by ischemia

  This study is looking at how special cells from human stem cells can help grow new blood vessels in people with critical limb ischemia, using a mouse model to see if these cells, combined with a special support material and a growth factor, can improve healing and blood flow in the affected limbs.

  NIH research University of California, Merced · Merced, United States · NIH-11046333

• How certain proteins control cell fate and gene expression

  This study is looking at how certain proteins help decide what type of cells we become during development and disease, which could lead to new ways to treat conditions like cancer and improve healing.

  NIH research University of California, Merced · Merced, United States · NIH-11041166

• Understanding how a specific protein helps protect cells from damage

  This study is looking at a protein called ABCB10 that helps move important substances out of our cells, especially in red blood cell production, and it aims to understand how this protein can protect the heart from damage, which could help find new ways to treat anemia and heart disease.

  NIH research University of California, Merced · Merced, United States · NIH-11034115

• How immigrant policies affect mental health and healthcare access for rural Latinos

  This study looks at how different immigration policies affect the mental health and healthcare access of Latino people living in rural areas, aiming to understand what makes it easier or harder for them to get the support they need.

  NIH research University of California, Merced · Merced, United States · NIH-11017014

• Understanding how biological clocks adapt to temperature and energy changes

  This study looks at how tiny bacteria called cyanobacteria keep their internal clocks running smoothly, even when temperatures and energy levels change, to help us understand how living things adapt to day and night.

  NIH research University of California, Merced · Merced, United States · NIH-11001557

• Understanding how microbes form communities on surfaces

  This study is looking at how groups of germs, called biofilms, form on things like medical devices and body tissues, and it aims to find ways to help prevent or treat infections caused by these germs, which could be really helpful for patients.

  NIH research University of California, Merced · Merced, United States · NIH-11001421

• Developing a vaccine to combat parasitic diseases using mRNA technology

  This study is working on a new vaccine to help protect people from infections caused by the Toxoplasma gondii parasite, using a special technology to boost the immune system's ability to recognize and fight off these infections.

  NIH research University of California, Merced · Merced, United States · NIH-11000339

• Using special cells and materials to improve blood flow in patients with critical limb ischemia

  This study is exploring a new way to help people with critical limb ischemia by using special cells that can boost blood vessel growth, hoping to improve blood flow and quality of life for those affected.

  NIH research University of California, Merced · Merced, United States · NIH-10999410

• How alcohol affects sleep and memory in the brain

  This study is looking at how just one drink can change your sleep and behavior, and it's for anyone curious about how alcohol affects our brains and sleep patterns, using both people and fruit flies to find out more.

  NIH research University of California, Merced · Merced, United States · NIH-10988050

• Investigating how blood vessels and cells help the thymus recover after cancer treatments

  This study is looking at how blood vessels and certain cells in the body help the thymus heal after chemotherapy for blood cancers, with the hope of finding ways to improve recovery and make treatments more effective for patients.

  NIH research University of California, Merced · Merced, United States · NIH-10982411

• Investigating how Candida albicans changes its form and affects infections

  This study is looking at how a common fungus called Candida albicans changes its form and behavior, which can affect how serious infections are, with the goal of finding better ways to treat these infections in patients.

  NIH research University of California, Merced · Merced, United States · NIH-10974826

• Understanding how temperature affects enzyme function and regulation

  This study looks at how changes in temperature affect enzymes, which are important for many processes in our bodies, to help scientists find better ways to create drugs that work more effectively for patients.

  NIH research University of California, Merced · Merced, United States · NIH-10895512

• Hydrogels that reduce inflammation by capturing inflammasomes

  This study is looking at a new type of gel that can help reduce harmful inflammation in the body, which could be helpful for people dealing with serious health issues like cancer or heart disease.

  NIH research University of California, Merced · Merced, United States · NIH-10870146

• Understanding how the immune system responds to Coccidioides infection

  This study is looking at how the immune system reacts to Valley fever, a fungal infection, to find ways to improve diagnosis and treatment, and it’s using mice to help figure out how we can better manage this disease and develop vaccines.

  NIH research University of California, Merced · Merced, United States · NIH-10731031

• Exploring how cellular forces influence the development of the endoderm layer in embryos

  This study looks at how physical forces help certain cells in zebrafish embryos develop into important organs like the gut and lungs, so we can better understand how these cells change and organize during growth.

  NIH research University of California, Merced · Merced, United States · NIH-10677673

• How human milk cortisol levels change throughout the day and affect infant health

  This study looks at how the hormone cortisol in breast milk changes throughout the day and how these changes might affect babies' sleep and wake patterns, helping us find ways to support healthier development for breastfeeding infants.

  NIH research University of California, Merced · Merced, United States · NIH-10653545

• Understanding how Hedgehog signaling works in cells

  This study is looking at how a specific signaling pathway in our cells, which is important for normal growth and can be linked to certain birth defects and cancers, works by focusing on a tiny part of the cell called the primary cilium, and it aims to find new ways to treat conditions related to this pathway.

  NIH research University of California, Merced · Merced, United States · NIH-10527729

• Exploring how leisure activities can help reduce the risk of heart disease

  This study is looking at how different fun activities can help reduce stress, depression, and sitting too much, and it’s for anyone interested in finding out which hobbies might improve heart health and overall well-being.

  NIH research University of California, Merced · Merced, United States · NIH-10360041

• Understanding how older adults process language differently than younger adults

  This study looks at how older adults understand and predict language compared to younger adults, to see if age affects their ability to guess what comes next in conversations, which could help improve communication for seniors.

  NIH research University of California, Merced · Merced, United States · NIH-10291114

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