Investigating how certain proteins recognize and respond to DNA from pathogens
DNA Binding Dynamics and Oligomerization of Sensors of the PYHIN family in Pattern Recognition
This study is looking at how certain proteins in your body recognize and respond to harmful germs, which could help us find new ways to treat autoimmune diseases and cancer by improving how your immune system reacts.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, Merced NIH-funded |
| Lab location | 1 site (Merced, United States) |
| Project ID | NIH-11200534 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific proteins, known as pattern recognition receptors, detect DNA from harmful bacteria and viruses. By studying the binding dynamics and oligomerization of the AIM2 and IFI16 proteins, the research aims to uncover how these proteins trigger inflammatory responses that are crucial for the body's defense against infections. The approach involves analyzing the 3D structures of these proteins and their interactions, which could lead to new insights into their roles in autoimmune diseases and cancer treatment. Patients may benefit from the development of targeted therapies that modulate these inflammatory responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune disorders or certain types of cancer that may be influenced by the AIM2 and IFI16 proteins.
Not a fit: Patients with conditions unrelated to inflammation or the specific mechanisms of AIM2 and IFI16 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new anti-inflammatory and anti-cancer therapies that improve patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for therapeutic interventions, indicating potential for success in this area.
Where this research is happening
Merced, United States
- University of California, Merced — Merced, United States (Active)
Researchers
- Principal investigator: De Alba Bastarrechea, Eva — University of California, Merced
- Study coordinator: De Alba Bastarrechea, Eva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.