Exploring how cellular forces influence the development of the endoderm layer in embryos
Official title: Determining the role of cellular forces in endoderm differentiation and development
Funded at University of California, Merced · NIH-10677673 · Data updated 2026-11-12
This study looks at how physical forces help certain cells in zebrafish embryos develop into important organs like the gut and lungs, so we can better understand how these cells change and organize during growth.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, Merced NIH-funded |
| Lab location | 1 site (Merced, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $144,345 |
| NIH project number | 5R21HD107313-02 |
| Project ID | NIH-10677673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to organ development or those interested in the biological mechanisms of tissue formation.
✕Less likely to help
Patients with fully developed organs or those not affected by developmental disorders may not benefit from this research.
What this research studies
This research investigates the role of mechanical forces in the differentiation and development of endodermal cells, which are crucial for forming organs like the gastrointestinal tract and respiratory system. By studying zebrafish embryos, which are transparent and allow for detailed observation, the research focuses on how these cells transition from a migratory state to forming organized tissues. The methodology includes long-term microscopy to observe changes in cell behavior and physical forces during this critical developmental phase.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of organ development and potentially lead to advances in regenerative medicine and treatments for developmental disorders.
How similar studies have gone: While the specific focus on mechanical forces in endoderm differentiation is relatively novel, related research has shown success in understanding cell behavior during development.
Where this research is happening
-
University of California, Merced
Merced, United States Active
Researchers
- Principal investigator: Woo, Stephanie — University of California, Merced
- Study coordinator: Woo, Stephanie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.