Understanding how a specific protein helps protect cells from damage
Official title: Molecular Mechanisms of The Human Mitochondrial ABC Transporter ABCB10
Funded at University of California, Merced · NIH-11034115 · Data updated 2026-11-12
This study is looking at a protein called ABCB10 that helps move important substances out of our cells, especially in red blood cell production, and it aims to understand how this protein can protect the heart from damage, which could help find new ways to treat anemia and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, Merced NIH-funded |
| Lab location | 1 site (Merced, United States) |
| Project start | April 1, 2022 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $273,976 |
| NIH project number | 5R01GM145938-04 |
| Project ID | NIH-11034115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from anemia or those at risk of heart conditions related to oxidative stress.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or oxidative stress may not benefit from this research.
What this research studies
This research investigates the ABCB10 protein, a crucial transporter in human cells that helps export substances out of the mitochondria, particularly during the formation of red blood cells. The study aims to identify the specific substances that ABCB10 transports and how it protects the heart from oxidative stress. By using advanced techniques like ATPase assays and spectroscopic analysis, researchers will explore the molecular mechanisms of this transporter, which could lead to new insights into treating conditions like anemia and heart disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for anemia and improved heart protection against oxidative damage.
How similar studies have gone: Previous research has shown promise in understanding similar transport proteins, indicating potential for success in this area.
Where this research is happening
-
University of California, Merced
Merced, United States Active
Researchers
- Principal investigator: Zoghbi, Maria Elena — University of California, Merced
- Study coordinator: Zoghbi, Maria Elena
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.