Sponsor or institution
Clinical trials and research at Univ of Arkansas for Med Scis
As of November 12, 2026, Find a Trial lists 230 NIH-funded research projects at this institution, with $130.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 230NIH research projects
NIH-funded research (newest 40 of 230)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Postpartum depression screening at well-child visits in Arkansas
A study examines whether adding depression screening at baby visits in Arkansas improves detection and care for new mothers.
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How the RORα protein affects breast cancer growth and inflammation
Researchers are looking at whether boosting the RORα protein in breast cells can lower harmful oxidative stress and immune inflammation that help breast cancer grow.
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PLOD2 and succinate: a metabolic switch that fuels breast cancer spread
A cancer research project is exploring how a metabolic change involving succinate and a key enzyme (PLOD2) may drive breast cancer cells to become more invasive and able to spread.
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Stopping steroid-related muscle and bone wasting in Duchenne muscular dystrophy
Researchers are testing ways to protect muscles and bones in people with Duchenne muscular dystrophy who take long-term steroid medicines.
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STAR+ Model for Hearing Diagnostics and Treatment in Rural Appalachian Children
A program that uses telehealth to connect rural school children with hearing specialists so they can get timely testing and treatment for hearing loss.
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Organoid model to study how malaria and EBV drive Burkitt lymphoma in children
A study uses human tonsillar organoids to understand how malaria parasite infection and EBV together may cause a type of lymphoma in children from sub-Saharan Africa.
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How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
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DNA repair enzymes: how polymerases shape end-joining in cancer-related DNA breaks
A patient-facing description of a research project that looks at how DNA repair enzymes handle damaged breaks in cancer-related cells to keep genomes stable.
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DNA helicases: How these molecular motors are turned on and off in cancer and aging
A NIH grant aims to understand how DNA helicases, tiny machines that help copy and repair DNA, are controlled and how their misregulation can lead to cancer, aging, and neurological diseases.
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Targeting RNF166 to prevent T-cell exhaustion in solid tumors
Aims to boost cancer-fighting T cells by modulating RNF166 to keep T cells active and persistent in solid tumors.
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Reducing heart risk in kidney disease patients with ticagrelor
A patient-friendly trial will test whether a heart medication called ticagrelor, added to standard care, can lower inflammation and markers linked to heart risk in people with chronic kidney disease.
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Health promotion to reduce pregnancy-related hypertension and maternal mortality in Arkansas
A statewide program in Arkansas aims to reduce pregnancy-related hypertension and maternal deaths by testing scalable, community-based strategies and measuring how well they can be adopted and sustained.
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Microvascular health in osteoarthritis: how blood vessels affect joints
This grant asks to explore how tiny blood vessels in the joint contribute to osteoarthritis and whether targeting them could shift disease outcomes to help patients.
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Innovative care pathways to screen and treat OUD/PTSD in jail settings
A new project will try to improve how jail-based programs screen for PTSD and OUD and link people to PTSD therapy and medications for OUD after release.
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HVIP+ Community Model: A Violence Prevention Program for Central Arkansas
A community violence prevention program in Arkansas aims to expand hospital-based violence intervention services to more counties and residents impacted by violence.
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HERV-K activation and targeted therapies for AIDS-related cancers
Aims to understand how a human retrovirus sequence called HERV-K is turned on in HIV/AIDS patients and how this might lead to new therapies for cancers like Kaposi’s sarcoma.
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Methionine restriction to protect the gut after radiation
This NIH grant tests whether reducing methionine in the diet can protect the gut from damage after high-dose radiation, using animal models to study GI-ARS.
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New metabolic pathway for halogenated drugs of abuse
A small NIH grant funds study on how halogenated drugs of abuse are processed in the body and how this impacts safety.
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Birth Defects Study to Understand Causes of Structural Birth Defects
A nationwide effort to find how genes and environment combine to cause structural birth defects, with the Arkansas Birth Defects study centers coordinating a pregnancy exposure look-back.
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Lung problems in osteogenesis imperfecta from collagen mutations in mice
This study looks at how collagen problems in the lungs contribute to breathing difficulties in a mouse model of osteogenesis imperfecta, with potential implications for patients who have similar bone and lung issues.
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Smartphone middle‑ear tester to spot preventable childhood hearing problems
This project builds a low-cost smartphone-based middle‑ear tester with smart software to find treatable hearing problems in children in low- and middle-income countries.
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Improving pregnancy risk predictions for Arkansas patients
This project compares two pregnancy risk scores to see how well they spot complications for younger and older, publicly or privately insured, and rural or urban pregnant people in Arkansas.
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Tailored services and childcare for pregnant women in opioid use disorder treatment
A national study looks at how pregnancy-focused addiction treatment programs can improve access to medications, childcare, and support for pregnant or new mothers with opioid use disorder.
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Remote glucose monitoring to help rural pregnant women with Type 2 diabetes
A pilot project tests whether remote glucose monitoring can improve prenatal care and outcomes for pregnant women with type 2 diabetes in rural areas.
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Digital Health Core to Improve Maternal and Reproductive Care in Arkansas
A hospital-affiliated program in Arkansas is creating digital health tools to improve access and quality of maternal and reproductive care for rural families.
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SUCCEED Core: Engaging Stakeholders to Improve Maternal and Reproductive Health
A hub supports researchers and communities to work together to improve maternal and reproductive health outcomes.
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Administrative Core for Maternal and Reproductive Health Research Center
A central Administrative Core will coordinate leadership, budgeting, and communication for a maternal and reproductive health research center to help researchers work together and sustain their programs.
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MaRCH COBRE: Building momentum for maternal and reproductive health in Arkansas
A dedicated center in Arkansas aims to boost maternal and reproductive health by growing local researchers, engaging communities, and using digital tools.
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Proteomics resource hub to advance cancer research
A nationwide proteomics resource center helps researchers study cancers by providing access to advanced proteomics tools, training, and data analysis support.
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Expanding Translational Science to Improve Arkansans’ Health
A multi-year NIH grant aims to bring faster, real-world health improvements to people in Arkansas by strengthening translational science and clinical research networks.
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Targeting Ryanodine Receptors to Prevent Lymphedema from Doxorubicin in Breast Cancer
This grant explores how a common chemotherapy drug (doxorubicin) may cause lymphedema in breast cancer patients and tests a viable approach to prevent or reduce it by modulating Ryanodine receptors.
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Protecting the retina by helping immune cells clear dead cells
A doctor-scientist-led project will explore how to boost the retina’s clean-up cells so they remove dying cells after injury, which could help people with diabetic retinopathy or other retinal diseases.
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Mitochondrial quality control and bone health in aging and estrogen loss
This grant studies how mitochondria in bone cells affect bone loss that happens with aging and low estrogen, with the goal of finding ways to protect bone strength.
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Screening and offering PTSD therapy to help jailed adults with opioid addiction
This project offers PTSD screening and therapy in jails to help adults with opioid use disorder begin and stay on medication treatment after release.
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Autophagy and bone health in brittle bone disease
A study in mice explores how boosting a cellular recycling process called autophagy can increase bone formation and strength in brittle bone disease.
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Epigenetic controls of KSHV latency in AIDS-related cancers
Aiming to understand how a herpesvirus keeps a deadly infection dormant in tumor cells of people with HIV, to uncover new ways to treat AIDS-related cancers.
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Platelets and immune problems after radiation
This grant studies how platelets may worsen immune problems after radiation exposure and tests platelet-based ideas to protect immune function and organs like the gut and heart.
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Osteocytes and bone disease in Multiple Myeloma: targeting local FGF23 to slow cancer and improve bone health
This grant explores whether blocking a bone-cell signal (FGF23) produced by osteocytes can slow multiple myeloma growth and reduce bone damage.
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Improving School-Parent Coordination to Prevent Nicotine Use among Rural Youth
A rural Arkansas program adapts a nicotine-prevention plan to fit local schools and families, aiming to reduce teen vaping and smoking and lower future health risks.
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Molecular controls of pituitary cell fate in adults
This NIH grant explores how the adult pituitary gland changes which hormones it makes, aiming to uncover drivers that could help treat endocrine or cardiovascular conditions.
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