Lung problems in osteogenesis imperfecta from collagen mutations in mice
Official title: Lung developmental defects caused by type I collagen mutations in mouse models of osteogenesis imperfecta
Funded at Univ of Arkansas for Med Scis · NIH-11394600 · Data updated 2026-11-12
This study looks at how collagen problems in the lungs contribute to breathing difficulties in a mouse model of osteogenesis imperfecta, with potential implications for patients who have similar bone and lung issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $380,533 |
| NIH project number | 5R01HL166748-04 |
| Project ID | NIH-11394600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with osteogenesis imperfecta or related skeletal dysplasias who experience respiratory problems.
✕Less likely to help
Patients without skeletal dysplasias or significant lung involvement may not directly benefit from these findings.
What this research studies
Researchers study mice lacking the Crtap gene and other COL1-related mutations to understand how lung development and function are affected in osteogenesis imperfecta. They examine lung cells, alveolar structure, and gene expression to pinpoint intrinsic lung abnormalities beyond skeletal issues. The work uses advanced techniques like spatial transcriptomics to map changes in lung tissue and assess respiratory mechanics in young mice. Findings could reveal targets to improve lung function for people with skeletal dysplasias that impact breathing.
Why it matters
Potential benefit: If successful, this research could identify ways to protect or improve lung development and breathing in patients with OI and similar skeletal disorders.
How similar studies have gone: Previous work in mouse models shows COL1-related lung changes and altered respiration, suggesting this approach has precedent, though human translation remains to be proven.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Morello, Roy — Univ of Arkansas for Med Scis
- Study coordinator: Morello, Roy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.