Platelets and immune problems after radiation
Official title: Platelets in radiation-induced immune dysregulation
Funded at Univ of Arkansas for Med Scis · NIH-11361071 · Data updated 2026-11-12
This grant studies how platelets may worsen immune problems after radiation exposure and tests platelet-based ideas to protect immune function and organs like the gut and heart.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | July 25, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $636,257 |
| NIH project number | 5U01AI170039-05 |
| Project ID | NIH-11361071 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have or may experience radiation exposure and related immune or organ complications could be affected by future advances from this work.
✕Less likely to help
The study is highly focused on basic mechanisms and may not directly benefit individuals who have no exposure to radiation or immune disorders.
What this research studies
If radiation exposure occurs, this project looks at how platelets interact with immune cells to drive immune dysregulation. Researchers will explore platelet-derived particles and platelet–leukocyte interactions to understand their role in ongoing immune problems after radiation. They will test platelet-centered strategies to reduce immune dysfunction and organ damage, focusing on the intestine and heart. The work involves experiments that could translate to new ways to prevent or lessen radiation-related immune complications.
Why it matters
Potential benefit: If successful, the research could lead to new platelet-based approaches to mitigate immune dysregulation and protect organs after radiation exposure.
How similar studies have gone: Previous research has shown platelets influence immune responses, but applying platelet-centered countermeasures to radiation-induced immune dysregulation is still an evolving area with proof-of-concept needed.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Pathak, Rupak — Univ of Arkansas for Med Scis
- Study coordinator: Pathak, Rupak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.