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Clinical trials and research at Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

• 63Clinical trials
• 2Countries

Newest trials

All recruiting trials (63)

• Adding 177Lu-PSMA-617 to EBRT and short ADT for high-risk localized prostate cancer

  This study tests whether adding a PSMA-targeted therapy before and during standard radiation plus a shorter 6-month hormone therapy is safe and may improve outcomes for men with high-risk localized prostate cancer.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07550517

• Precision radiotherapy guided by molecular MRI (APT imaging)

  This project will test whether a special MRI scan called amide proton transfer (APT) imaging can better identify the most aggressive areas of glioblastoma to guide radiotherapy in adults.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07512154

• DNAJB1-PRKACA vaccine plus DRP-104, nivolumab, and ipilimumab for advanced fibrolamellar liver cancer

  A early-stage study tests whether a personalized vaccine plus two immune drugs and a glutamine-blocking agent can safely help people with advanced fibrolamellar liver cancer.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07430202

• Ruxolitinib for IEC-HS after CAR-T therapy

  This pilot study tests whether ruxolitinib can help treat IEC-HS that can occur after CAR-T therapy in adults.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07424222

• Music therapy for patients with newly diagnosed GBM after chemoradiation

  This study tests whether adding music therapy helps improve quality of life for adults with newly diagnosed glioblastoma who are receiving standard treatment.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07375992

• Total pancreatectomy with islet transplantation for high-risk periampullary pancreatic tumors

  This study tests whether adults with periampullary tumors who are at high risk of pancreatic fistula after surgery can safely undergo total pancreatectomy with islet autotransplantation as an alternative approach.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07360119

• Capecitabine/Oxaliplatin chemo with cemiplimab with or without fianlimab or REGN7075 for locally advanced rectal cancer

  This trial tests whether adding cemiplimab, cemiplimab with fianlimab, or cemiplimab with REGN7075 to CAPOX can help people with MSS locally advanced rectal cancer before surgery.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07281768

• Neoadjuvant chemoimmunotherapy with PD-1 blockade to reduce surgery for advanced head and neck cancer

  This approach will try a short course of chemotherapy plus the PD-1 drug toripalimab before standard treatment for people with advanced head and neck cancers to shrink tumors and allow less extensive surgery or radiation.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07209189

• Reducing doctor and patient barriers to genomic (NGS) testing for metastatic prostate cancer

  This project will try two approaches—supporting doctors and supporting patients—to increase genomic (NGS) testing for men with metastatic prostate cancer at Johns Hopkins.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07209176

• Alternating high-dose testosterone with darolutamide to extend hormone response in metastatic prostate cancer

  This trial will test whether alternating high-dose testosterone with the antiandrogen darolutamide can prolong hormone control and improve quality of life for men with metastatic castration-resistant prostate cancer.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07142551

• DK222 PET imaging at Johns Hopkins

  This Phase 1 trial will test a PET imaging agent called [18F]DK222 in adults with non-small cell lung cancer or urothelial cancer who are eligible for PD-1/PD-L1 therapy to see if it is safe and how it distributes and how much radiation it gives off.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07140315

• Registry of pediatric proton and photon radiation therapy

  This registry will collect detailed 3D radiation dose data and health outcomes from children and young adults treated with proton or photon therapy to see how treatment type relates to long-term side effects and quality of life.

  Recruiting at 2 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT07129317

• Momelotinib plus azacitidine for chronic-phase MDS/MPN and chronic neutrophilic leukemia

  This trial will test whether adding momelotinib to a standard hypomethylating drug helps adults with chronic-phase MDS/MPN or chronic neutrophilic leukemia control their disease and symptoms.

  Recruiting Early Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07071155

• 111In-XYIMSR-01 SPECT/CT to find metastatic clear-cell kidney cancer

  This trial tries a radioactive tracer called 111In-XYIMSR-01 during a SPECT/CT scan to see if it can find metastatic clear-cell kidney cancer in adults.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07062549

• NC410 plus FOLFIRINOX with nivolumab, with or without ipilimumab, for untreated metastatic pancreatic cancer

  This trial tests whether adding NC410 to standard FOLFIRINOX with nivolumab (and sometimes ipilimumab) is safe and tolerable for adults with untreated metastatic pancreatic cancer.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06941857

• Combining high-dose testosterone with ZEN-3694, then enzalutamide plus ZEN-3694 for resistant prostate cancer

  This trial will test whether cycles of high-dose testosterone together with ZEN-3694, followed by enzalutamide plus ZEN-3694, can shrink tumors or delay progression in men with metastatic castration‑resistant prostate cancer who have progressed on prior AR-directed therapy.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06922318

• Proton therapy for spinal tumors

  This study is testing if proton therapy can help people with tough-to-treat spinal tumors feel better by targeting the tumors more precisely while protecting nearby healthy tissue.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06895564

• 7-day water-only fasting for metastatic prostate cancer

  This study will test whether a 7-day water-only fast (with a ketogenic very low-calorie option) is safe and doable for people with metastatic prostate cancer.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06826924

• Comparing two doses of total body irradiation for leukemia patients undergoing stem cell transplant

  This study is testing whether a lower or higher dose of total body radiation helps leukemia patients doing a stem cell transplant have better chances of staying healthy and not relapsing.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06803745

• Targeted radiation therapy for young patients with metastatic sarcoma

  This study is testing if a special type of radiation therapy can help young patients with metastatic sarcoma live longer and have fewer health issues compared to those who don’t receive it.

  Recruiting at 3 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 2 other locations · NCT06796543

• GVAX versus a mutated-KRAS peptide vaccine plus immune antibodies before and after surgery for resectable pancreatic cancer

  This trial tests whether giving AGEN2373 and the immune antibody balstilimab together with either GVAX or a mutated-KRAS peptide vaccine is safe and helpful for people with newly diagnosed, surgically resectable pancreatic cancer.

  Recruiting Phase 1/2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06782932

• Observational study for patients with breast cancer leptomeningeal metastasis

  This study is trying to learn more about breast cancer patients with leptomeningeal metastasis by collecting samples and providing better treatment options to improve their care.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT06638294

• Targeting gut bacteria to improve prostate cancer treatment

  This study is testing if adding a gut bacteria-targeting medication to standard prostate cancer treatment can help men with advanced prostate cancer respond better to their therapy.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06616597

• Using blood and cerebrospinal fluid tests to monitor treatment in BRAF-altered glioma

  This study is testing if a new targeted therapy can help people with a specific type of brain tumor by checking their blood and spinal fluid for signs of the tumor during treatment.

  Recruiting Early Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland and 1 other locations · NCT06610682

• Targeting driver oncogenes in biliary tract cancer with a personalized peptide vaccine plus durvalumab and tremelimumab

  This trial will test whether a personalized mutant peptide vaccine given with durvalumab and tremelimumab is safe and stimulates an immune response in people with advanced biliary tract cancer after first-line chemotherapy and anti–PD-(L)1 therapy.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06564623

• Water-only fasting to improve chemotherapy for early-stage breast cancer

  This study is testing if fasting for 24-48 hours can help make chemotherapy work better and be easier to tolerate for people with early-stage breast cancer.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia · NCT06536881

• Exploring personalized biomarkers during radiation therapy for chordoma

  This study is testing if tracking changes in tumor DNA during radiation therapy can help doctors better understand how chordoma patients are responding to treatment.

  Recruiting at 2 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland and 1 other locations · NCT06463262

• Vaccine treatment for advanced colorectal and pancreatic cancer

  This study is testing a new vaccine combined with two other treatments to see if it can help people with advanced colorectal and pancreatic cancer who haven't responded to their first treatment.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06411691

• Using Darzalex Faspro to lower antibody levels before stem cell transplant

  This study is testing if a new treatment called Darzalex Faspro can help lower harmful antibodies in adults so they can safely receive a stem cell transplant for blood cancers.

  Recruiting Early Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06398457

• Imaging for treatment optimization in advanced prostate cancer

  This study is testing if special imaging can help doctors understand how well radiation treatments work for people with advanced prostate cancer and improve their outcomes.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06389097

• Proton therapy for kidney cancer treatment

  This study is testing if proton therapy can help people with kidney cancer who can't have surgery by improving their treatment outcomes while protecting their healthy kidney tissue.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia · NCT06376669

• PVX7 immunotherapy for advanced cervical cancer

  This test tries two ways of giving the PVX7 vaccine to see if it is safe and triggers immune responses in people with advanced cervical cancer who finished their main treatment.

  Recruiting at 2 sites Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Birmingham, Alabama and 1 other locations · NCT06315257

• Using PET scans to guide treatment for triple negative breast cancer

  This study tests if using PET scans can help doctors tailor treatment for people with stage 2 and 3 triple negative breast cancer to improve their chances of a successful surgery.

  Recruiting at 2 sites Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland and 1 other locations · NCT06245889

• pBI-11 DNA vaccine delivered by electroporation for HPV16/18 cervical infection

  This study tests whether the pBI-11 DNA vaccine given with an electroporation device is safe and feasible and may help clear HPV16/18 in women with persistent cervical infection.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Birmingham, Alabama and 1 other locations · NCT06210854

• Cemiplimab with or without Fianlimab for older patients with advanced colorectal cancer

  This study is testing whether a new combination of two immunotherapy drugs can help older patients with advanced colorectal cancer feel better and improve their treatment outcomes.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06205836

• Personalized exercise program for men with metastatic prostate cancer

  This study will try a 12-week personalized aerobic and resistance exercise program to see if it lowers circulating tumor cells in men with advanced prostate cancer.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06165302

• High- vs Low-Intensity Patient Navigation to Increase Patient Participation in Cancer Clinical Programs

  This project tests whether a high-intensity patient navigation program helps adults with prostate or kidney cancer enroll in clinical trials more than a lower-intensity navigation approach.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland and 1 other locations · NCT06138067

• Combination treatment for advanced prostate cancer using DFMO, testosterone, and enzalutamide

  This study is testing a new combination of treatments using DFMO, testosterone, and enzalutamide to see if it can help men with advanced prostate cancer that hasn't responded to previous therapies.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06059118

• Treatment for potentially resectable biliary tract cancers using a combination of drugs

  This study is testing a combination of three drugs to see if they can help people with newly diagnosed biliary tract cancers before surgery.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06001658

• Collection of blood and tissue samples from patients with upper aerodigestive cancers

  This study is collecting blood and tissue samples from patients with certain cancers to see how their treatments affect the immune system and to help improve future cancer therapies.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05995821

• Peptide vaccine to prevent resistance in advanced lung cancer

  This study is testing a new vaccine to see if it can help people with advanced lung cancer who are on specific treatments avoid or delay their cancer from becoming resistant.

  Recruiting Phase 1/2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05950139

• Pre-operative proton therapy for soft tissue sarcoma

  This study tests if a special type of radiation therapy given before surgery can help people with soft tissue sarcomas in their arms or legs heal better and have a better quality of life afterward.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia · NCT05917301

• Minimizing radiation impact on cognitive function in children with brain tumors

  This study is testing if a special way of planning radiation treatment can help protect the thinking skills of children with brain tumors while they receive their therapy.

  Recruiting at 2 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT05658731

• Combination therapy for high grade upper tract urothelial cancer patients refusing surgery

  This study is testing if a combination of two cancer drugs can help people with high grade upper tract urothelial cancer who don't want surgery live longer without their cancer getting worse.

  Recruiting at 2 sites Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT05656235

• Using blood tests to guide cancer treatment decisions

  This study tests if blood tests can help doctors find the best cancer treatments for patients with solid tumors and see how well those treatments are working.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05585684

• Screening program for heart and metabolic health in breast cancer survivors

  This study is testing a screening program for women who have survived early-stage breast cancer to see if it helps identify and manage heart and metabolic health risks like diabetes and heart disease.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05386719

• Combining Atezolizumab with Etoposide and Platinum for Small Cell Bladder Cancer

  This study is testing if a new combination of atezolizumab, etoposide, and platinum-based chemotherapy can help people with advanced small cell bladder cancer respond better to treatment before surgery.

  Recruiting at 2 sites Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT05312671

• Vaccine combined with immune therapy for advanced lung cancer

  This study is testing a new vaccine combined with immune therapy to see if it can help people with advanced lung cancer live longer and feel better.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05254184

• Combining carmustine wafers with retifanlimab and radiation for glioblastoma treatment

  This study is testing if combining carmustine wafers with retifanlimab and radiation can help adults with newly diagnosed glioblastoma live longer and feel better after surgery.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT05083754

• Using Cemiplimab with or without chemotherapy for HPV-related head and neck cancer

  This study is testing if a new immunotherapy called Cemiplimab, with or without chemotherapy, can help people with HPV-related head and neck cancer while making treatment easier and improving their quality of life.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT04988074

• Combining radiotherapy and radioactive iodine for thyroid cancer treatment

  This study is testing whether combining radioactive iodine and external beam radiotherapy can safely improve treatment for people with recurrent thyroid cancer that has spread and can't be fully removed.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT04892303

• Combining Bipolar Androgen Therapy with Radium-223 for advanced prostate cancer

  This study is testing whether combining a new hormone treatment with a radiation therapy can help men with advanced prostate cancer feel better and improve their health.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland and 1 other locations · NCT04704505

• Registry for patients receiving proton radiation therapy

  This study is collecting information from patients who receive proton radiation therapy to see how well it works and who benefits the most from it.

  Recruiting at 4 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 3 other locations · NCT04376229

• Sequential Testosterone and Enzalutamide treatment for advanced prostate cancer

  This study is testing if alternating high-dose testosterone with enzalutamide can help men with advanced prostate cancer do better than just taking enzalutamide alone.

  Recruiting at 6 sites Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · San Diego, California and 5 other locations · NCT04363164

• Vaccine treatment combined with immune therapy for a type of liver cancer

  This study is testing a new vaccine combined with immune therapy to see if it can help people with a specific type of liver cancer feel better and fight the disease.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT04248569

• Reduced intensity bone marrow transplant for immune and bone marrow disorders

  This study is testing a gentler type of bone marrow transplant to see if it can help people with immune and bone marrow disorders recover better and live longer.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT04232085

• HPV DNA vaccine for treating cervical neoplasia

  This study is testing a new HPV DNA vaccine to see if it is safe and effective for women with certain types of cervical changes caused by HPV.

  Recruiting at 2 sites Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Birmingham, Alabama and 1 other locations · NCT04131413

• Image-guided focal brachytherapy for prostate cancer using advanced PET imaging

  This study is testing a new way to treat prostate cancer by using advanced imaging to target only the tumors that need treatment while protecting healthy areas to reduce side effects.

  Recruiting Early Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT03861676

• Olaparib treatment for patients with metastatic kidney cancer and specific gene mutations

  This study is testing if the oral medication olaparib can help people with advanced kidney cancer who have certain gene mutations and have already tried other treatments.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT03786796

• Nivolumab treatment for advanced basal cell carcinoma

  This study is testing if the drug nivolumab, alone or with other medications, can help people with advanced basal cell carcinoma that can't be removed by surgery.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT03521830

• Using Nivolumab after Half-Matched Bone Marrow Transplant for Sarcoma

  This study is testing if a new drug called Nivolumab can help prevent or delay the return of high-risk sarcomas in children and adults after they receive a special type of bone marrow transplant.

  Recruiting at 3 sites Phase 1/2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · St. Petersburg, Florida and 3 other locations · NCT03465592

• Using MRI to improve gynecologic cancer treatment with brachytherapy

  This study is testing if using MRI instead of traditional CT scans can help improve brachytherapy treatment for women with gynecologic cancers by better targeting tumors and reducing radiation exposure to healthy tissues.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT02993900

• Reduced intensity bone marrow transplant for high-risk solid tumors

  This study is testing a new way to use a less intense chemotherapy and a special type of bone marrow transplant to help people with very high-risk solid tumors fight their cancer.

  Recruiting at 3 sites Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland and 2 other locations · NCT01804634

Quick answers

How many clinical trials run by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins are recruiting right now?

63, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (63 trials), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 22, Phase 1: 12, Early Phase 1: 4, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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