Understanding how genes and aging affect female ovarian health
Official title: Molecular Mechanisms and Genetic Basis of Human Ovarian Aging
Funded at Columbia University Health Sciences · NIH-11551155 · Data updated 2026-11-12
A funded project at Columbia University aims to uncover how aging changes the ovaries at the gene level and to identify genetic factors linked to when women reach menopause.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $168,803 |
| NIH project number | 3RF1AG093116-01S1 |
| Project ID | NIH-11551155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women whose ovarian tissue or cells can be studied to understand aging and menopause timing.
✕Less likely to help
This work is focused on laboratory investigations and may not directly involve patient care during the project period.
What this research studies
This project studies human ovaries across ages to map how regulatory genes change over time. It uses advanced genetic techniques and CRISPR-based tests to pinpoint variants that influence ovarian aging. The work relies on precise measurements in human tissues and cellular models to connect genetics with functional outcomes. An essential equipment upgrade will keep these tests running smoothly and ensure the research stays on track through the planned period.
Why it matters
Potential benefit: If successful, findings could improve understanding of menopausal timing and ovarian aging, potentially guiding women's health decisions.
How similar studies have gone: Previous studies have linked genetic variants to menopause timing, and this work aims to build on that foundation with cellular and regulatory insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Suh, Yousin — Columbia University Health Sciences
- Study coordinator: Suh, Yousin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.