Sponsor or institution
Clinical trials and research at Cold Spring Harbor Laboratory
As of November 12, 2026, Find a Trial lists 123 NIH-funded research projects at this institution, with $72.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 123NIH research projects
NIH-funded research (newest 40 of 123)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding cancer cachexia and its drivers to improve patient care
A research team at Cold Spring Harbor Laboratory is studying why cancer patients lose weight and muscle and how to help prevent or treat that loss.
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Brain cancer and brain-glia communication: how tumor cells and microglia talk to each other to drive gbm growth
A patient-facing look at how GBM tumors may manipulate brain immune cells to grow, and how understanding this communication could lead to new treatments.
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Whole-Body Redox Maps to Guide Prostate Cancer Therapy
A new research project will map redox states across the body to understand how prostate cancer and its spread respond to therapy.
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Understanding how fats in tumors affect immune attack and cancer growth
This project looks at how lipid production in cancer cells influences their growth and how the immune system fights the tumor, and how dietary fats might change that interaction.
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High-throughput mapping of brain circuits using MAPseq and BARseq for autism research
A new set of fast, DNA-sequencing–based tools helps scientists map brain wiring in animals to better understand conditions like autism.
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A new software tool for analyzing nascent RNA data to study cancer biology
A new probabilistic software framework will help scientists study how cancer-related genes start and grow by analyzing nascent RNA sequencing data.
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Interpretable computer models for how DNA controls gene activity
A scientist at Cold Spring Harbor Lab is using advanced computer methods to understand how DNA switches control which genes are read, aiming to reveal clearer rules behind gene regulation.
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RNA interference and genome regulation across cells and diseases
This NIH grant supports research to understand how RNA interference helps silence genes and keep genome stability, with potential implications for autoimmune diseases and cancer.
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Natural products to block KLK6 and stop early pancreatic cancer progression
Aims to find natural compounds that inhibit KLK6 to help prevent early pancreatic cancer from becoming invasive.
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Molecular ideas behind how axo-axonic synapses form in the cortex
Scientists are studying how chandelier cells connect with other brain cells in the cortex to shape the way neurons fire, with potential relevance to autism.
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Understanding how autoimmune antibodies against NMDAR arise and affect the brain
A research team will explore how antibodies against the brain receptor NMDAR develop in cancer patients and how these autoantibodies cause a severe brain disorder.
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Understanding how smell and movement shape each other in mice
This grant studies how mice use their own movements to shape how they smell things, and how smelling then guides their next actions.
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SOAT1 as a target in pancreatic cancer
Researchers are studying a specific enzyme, SOAT1, to see if blocking it can slow down or stop pancreatic cancer progression in models that mimic human disease.
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Epigenetic reprogramming to restore tumor suppression in brain cancer
A new approach aims to reactivate the brain’s natural tumor-suppressing signals in glioblastoma patients by targeting a specific epigenetic regulator.
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Understanding NMDA brain receptors and how to target them
Researchers are mapping the shapes and drug-binding sites of NMDA brain receptors to guide new treatments for conditions like Alzheimer's, depression, and epilepsy.
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Glucocorticoid rhythm restoration in breast cancer
Aims to understand and help restore daily cortisol rhythms in people with breast cancer to improve quality of life and potentially survival.
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Making deep‑learning explanations for DNA more reliable
This project improves computer methods that explain which parts of DNA control gene activity so researchers — and eventually patients — can better understand genetic effects.
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Ketogenic diet may slow tumor growth but worsen cancer cachexia and survival
A research grant explores how a ketogenic diet affects cancer and body wasting, focusing on two mouse cancer models to understand why tumors respond differently from the patient’s overall health.
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Harnessing CAR T cells to unravel aging hallmarks in people with diabetes and heart disease
Researchers are testing a CAR T cell approach to target aging-related cell states that may influence heart disease and diabetes in adults.
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POU2F3-positive tuft cell–like cancers
Researchers will look for what makes a rare tumor called POU2F3-positive tuft cell–like carcinoma grow and identify weak spots that could be targeted by future treatments.
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Safer NMDA‑targeting antibodies for triple‑negative breast cancer
Developing new antibodies that target NMDA receptors to kill triple‑negative breast cancer cells while avoiding harmful brain side effects.
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Understanding how childhood T cell development shapes adult autoimmune diseases
This grant looks at how genetic differences influence T cell development in children and how that affects autoimmune diseases later in life.
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Boosting immune cell fat-burning to help fight metastatic colon cancer
This project tries to turn on a fat-burning program in immune cells to help immunotherapy work better for people with metastatic colorectal (colon) cancer, especially the common microsatellite-stable type.
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Tools to determine a patient’s genetic ancestry from cancer samples
Aimed at developing software to infer a person’s ancestral background using cancer-derived molecular data, without needing a separate genotyping test.
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Living mini-tumors (organoids) for breast and pancreatic cancer research
They grow tiny 3-D tumor models from patient samples to help researchers develop better treatments for breast and pancreatic cancers.
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Targeting regulatory RNAs in triple-negative breast and basal pancreatic cancer
This project looks at whether turning off a cancer-linked RNA called MALAT1 can slow aggressive triple-negative breast or basal pancreatic cancers.
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How mis-spliced RNA can drive pancreatic and breast cancer
This work looks at how abnormal RNA splicing in pancreatic and breast cancers could reveal new targeted treatments for people with those cancers.
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Stopping genes that drive breast and pancreatic cancers
The project tests ways to shut down gene switches (like KLF5 and YAP/TEAD) that help breast and pancreatic cancer cells grow, using patient-derived tissue models.
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Stopping cancer by targeting gene transcription and RNA splicing
Researchers are developing therapies that change how cancer cells read genes and process RNA to treat aggressive breast and pancreatic cancers.
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Understanding how neuron-OPC connections relate to autism
This NIH grant explores how tiny communication points between brain cells called neurons and oligodendrocyte precursor cells may influence autism, with findings that could guide future therapies.
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How human evolution shapes our genes and gene regulation
Researchers use large-scale human DNA data, AI, and evolutionary methods to find DNA changes and regulatory elements that affect health and cancer risk.
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How cells edit gene messages before making proteins
This project is learning how human cells cut and join RNA messages to control which proteins are produced, with the goal of helping people with genetic diseases caused by splicing errors like Duchenne muscular dystrophy.
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Support cells that trim extra brain connections during early development
This project will learn if a type of brain support cell called oligodendrocyte precursor cells removes extra nerve connections during early life, which may matter for children with autism.
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Understanding how colorectal polyps become cancer without mutations
This grant studies the non-mutational steps that let colorectal polyps turn into cancer, using a new mouse model that mirrors human disease and helps identify when and why progression happens.
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Targeted K-Ras(G12C) therapy that degrades the mutant protein and releases local chemotherapy
A new targeted treatment aims to tag and degrade the K‑Ras(G12C) cancer protein while releasing chemotherapy agents directly inside tumors for people whose cancers carry the K‑Ras(G12C) mutation.
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How a fat-like molecule controls a key enzyme linked to brain health and some cancers
Researchers are looking at whether a natural fat-like molecule called phosphatidic acid controls an enzyme (glutaminase) that affects brain function, acid balance, and certain cancers.
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Early short‑lived brain connections in Fragile X syndrome
This project looks at how early‑life brain wiring shapes later development in Fragile X syndrome and whether changing that wiring could help children with FXS.
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How early hormones and gene switches shape male and female brains
This project looks at how early-life hormones and epigenetic gene changes shape brain differences that relate to autism and other mental health conditions.
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Targeting the vitamin B6 pathway in acute myeloid leukemia
This research looks at whether blocking the vitamin B6 pathway can help treat people with acute myeloid leukemia.
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How gene changes shape cancer cells
The team is building computer tools to understand how combinations of gene changes alter cancer cells, to help researchers find better treatment targets for people with cancer.
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