Targeting the vitamin B6 pathway in acute myeloid leukemia
Characterizing vitamin B6 pathway dependency in acute myeloid leukemia
['FUNDING_R37'] · COLD SPRING HARBOR LABORATORY · NIH-11257716
This research looks at whether blocking the vitamin B6 pathway can help treat people with acute myeloid leukemia.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-11257716 on ClinicalTrials.gov |
What this research studies
From a patient perspective, scientists will examine leukemia cells and bone marrow samples to find which enzymes in the vitamin B6 pathway AML cells depend on. They will use genetic tools such as CRISPR screens and laboratory models to turn off those genes and see how leukemia cells respond compared with normal blood stem cells. The team will test drug-like approaches and combinations that inhibit key enzymes to identify potential drug targets. Successful targets would then be moved toward further preclinical testing and possible early-phase patient studies.
Who could benefit from this research
Good fit: Adults with acute myeloid leukemia, especially those with relapsed or refractory disease or whose leukemia shows signs of vitamin B6 pathway activity, would be the most relevant candidates.
Not a fit: People with other cancers, patients whose leukemia does not rely on the vitamin B6 pathway, or those seeking immediate clinical treatment are unlikely to receive direct benefit from this lab-focused project.
Why it matters
Potential benefit: If successful, this work could uncover new targeted therapies that kill AML cells while sparing normal blood cells, potentially improving effectiveness and reducing toxicity.
How similar studies have performed: This is a novel approach with promising laboratory evidence for vitamin B6 dependency but it has not yet produced proven patient treatments.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, LINGBO — COLD SPRING HARBOR LABORATORY
- Study coordinator: ZHANG, LINGBO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.