Molecular ideas behind how axo-axonic synapses form in the cortex
Official title: Molecular mechanisms underlying the assembly of axo-axonic synapses in the cerebral cortex
Funded at Cold Spring Harbor Laboratory · NIH-11368020 · Data updated 2026-11-12
Scientists are studying how chandelier cells connect with other brain cells in the cortex to shape the way neurons fire, with potential relevance to autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project start | September 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $897,709 |
| NIH project number | 1R01MH140858-01A1 |
| Project ID | NIH-11368020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with autistic disorder whose brain circuitry may be influenced by chandelier cell connections and related synapses.
✕Less likely to help
Results may not directly benefit individuals if findings are still in early, basic stages or applicable only to non-human models.
What this research studies
This project aims to uncover the molecular steps that guide chandelier cells to form synapses at the axon initial segment of pyramidal neurons, which is crucial for controlling neural output. Using advanced imaging and molecular techniques, researchers will map how these connections are established and stabilized during development. The work focuses on human-relevant brain circuitry and seeks to translate basic findings into insights about autistic disorders.
Why it matters
Potential benefit: A deeper understanding of how specific brain connections form could lead to new ideas for therapies that target circuit function in autism and related conditions.
How similar studies have gone: Previous research links chandelier cell connectivity to neurodevelopmental disorders, and identifying molecular mechanisms could advance this area.
Where this research is happening
-
Cold Spring Harbor Laboratory
Cold Spring Harbor, United States Active
Researchers
- Principal investigator: Van Aelst, Linda — Cold Spring Harbor Laboratory
- Study coordinator: Van Aelst, Linda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.