Venous clot complications after a first VTE in adults
Official title: Venous Thromboembolism Sequelae in a Population-based Inception Cohort
Funded at Kaiser Foundation Research Institute · NIH-11332768 · Data updated 2026-11-12
This study follows adults after a first venous thromboembolism to understand chronic symptoms and health outcomes over the first year.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $797,261 |
| NIH project number | 5R01HL166292-04 |
| Project ID | NIH-11332768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who have recently experienced a first venous thromboembolism and are under active follow-up.
✕Less likely to help
Persons without a recent VTE or those not under ongoing follow-up may not directly benefit from this study.
What this research studies
Researchers will track adults who recently had a first VTE to see how many develop ongoing symptoms such as shortness of breath, leg pain, and swelling, and how often serious outcomes like clot recurrence or death occur within 12 months. The project will compare people treated with different anticoagulants (including newer DOACs) and assess how physical activity and simple blood markers relate to these sequelae. Data will come from an inception cohort with active follow-up and real-world treatment patterns, aiming to identify who is most at risk and what might be done to prevent problems. The findings could inform clinicians and patients about long-term care needs after a VTE and guide future prevention strategies.
Why it matters
Potential benefit: If successful, the study could help clinicians predict who is at higher risk for long-term VTE-related problems and tailor care to prevent complications.
How similar studies have gone: Previous work has documented post-thrombotic syndrome after DVT; this study extends focus to post-PE and real-world anticoagulant use, which is relatively novel.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Harrington, Laura Brienne — Kaiser Foundation Research Institute
- Study coordinator: Harrington, Laura Brienne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.