Using stem cell-derived vesicles to improve heart function after heart attacks
Full-scale GMP Production for a Pre-Clinical Systemic Delivered Mesenchymal Stem Cells Derived Extracellular Vesicles For Cardiovascular Disease
This study is looking at how tiny particles from special stem cells can help improve heart function in people who have had a heart attack, with the hope of creating a new treatment that helps heal the heart instead of just treating the symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10895534 on NIH RePORTER |
What this research studies
This research investigates the use of extracellular vesicles derived from mesenchymal stem cells to enhance heart function in patients who have suffered a heart attack. The approach focuses on developing a large-scale production method for these vesicles, which are believed to help repair heart tissue and reduce inflammation. By utilizing advanced bioreactor technology, the study aims to ensure consistent quality and effectiveness of the vesicles for potential clinical use. Patients may benefit from a novel treatment that targets the underlying issues of heart failure rather than just alleviating symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are suffering from heart failure.
Not a fit: Patients with heart failure not related to myocardial infarction or those with other underlying health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a groundbreaking treatment that improves heart function and recovery in patients with heart failure.
How similar studies have performed: Previous research has shown promising results using stem cell-derived extracellular vesicles for cardiac repair, indicating potential for success in this approach.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Hare, Joshua M — University of Miami School of Medicine
- Study coordinator: Hare, Joshua M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.