Using stem cell-derived vesicles to improve heart function after heart attacks
Official title: Full-scale GMP Production for a Pre-Clinical Systemic Delivered Mesenchymal Stem Cells Derived Extracellular Vesicles For Cardiovascular Disease
Funded at University of Miami School of Medicine · NIH-10895534 · Data updated 2026-11-12
This study is looking at how tiny particles from special stem cells can help improve heart function in people who have had a heart attack, with the hope of creating a new treatment that helps heal the heart instead of just treating the symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $213,492 |
| NIH project number | 5U01HL169362-02 |
| Project ID | NIH-10895534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a myocardial infarction and are suffering from heart failure.
✕Less likely to help
Patients with heart failure not related to myocardial infarction or those with other underlying health conditions may not benefit from this research.
What this research studies
This research investigates the use of extracellular vesicles derived from mesenchymal stem cells to enhance heart function in patients who have suffered a heart attack. The approach focuses on developing a large-scale production method for these vesicles, which are believed to help repair heart tissue and reduce inflammation. By utilizing advanced bioreactor technology, the study aims to ensure consistent quality and effectiveness of the vesicles for potential clinical use. Patients may benefit from a novel treatment that targets the underlying issues of heart failure rather than just alleviating symptoms.
Why it matters
Potential benefit: If successful, this research could lead to a groundbreaking treatment that improves heart function and recovery in patients with heart failure.
How similar studies have gone: Previous research has shown promising results using stem cell-derived extracellular vesicles for cardiac repair, indicating potential for success in this approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Hare, Joshua M — University of Miami School of Medicine
- Study coordinator: Hare, Joshua M
Related research
Other NIH-funded projects on the same topics.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Food allergy antibodies linked to heart disease risk in adults
Many adults have antibodies to foods without symptoms, and this study asks whether those antibodies are linked to higher risk of heart disease and related conditions.
-
Mindfulness training to lower cardiovascular risk for moms and babies during pregnancy
A mindfulness program is being tested during pregnancy to help prevent high blood pressure and heart problems for mothers and their babies.
-
Integrating clinical pharmacists into HIV care to reduce cardiovascular disease in people with HIV
A pharmacist-led program in HIV care aims to prevent and manage heart disease risks like high blood pressure, diabetes, and high cholesterol in people living with HIV.
-
Integrating heart care into HIV services in Botswana using statins
This project tests a simple, scalable approach to help people with HIV in Botswana start and stay on statin therapy to prevent heart attacks and strokes.
-
A heart-healthy program for aging HIV patients using therapy pets to help blood pressure
A study tests whether using the human-animal bond from dog ownership can help older adults living with HIV control their blood pressure and improve heart health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.