Using cooling techniques to protect the spleen during ischemic stroke
Official title: Neuroprotection of Remotely Administered Hypothermia on Spleen in Ischemic Stroke
Funded at Wayne State University · NIH-10809221 · Data updated 2026-11-12
This study is exploring a new way to help protect the brain during a stroke by cooling the spleen from a distance, which might help reduce inflammation and improve recovery for stroke patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $423,500 |
| NIH project number | 1R21NS132006-01A1 |
| Project ID | NIH-10809221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are within the acute phase of treatment.
✕Less likely to help
Patients who have had hemorrhagic strokes or those with chronic conditions that prevent participation in acute interventions may not benefit from this research.
What this research studies
This research investigates a novel approach to protect the brain during ischemic stroke by remotely inducing hypothermia in the spleen. The goal is to reduce inflammation caused by stroke, which can worsen brain damage. By cooling the spleen, the researchers aim to suppress harmful inflammatory responses that occur after a stroke, potentially improving recovery outcomes. The study builds on previous findings that link spleen function and brain recovery in stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery for stroke patients.
How similar studies have gone: Previous studies have shown promising results in using hypothermia for neuroprotection, indicating that this approach may be viable.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Ding, Yuchuan — Wayne State University
- Study coordinator: Ding, Yuchuan
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
-
Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.