How biological aging and blood proteins relate to thinking after a stroke
Official title: Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors
Funded at University of Florida · NIH-11470695 · Data updated 2026-11-12
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | March 15, 2023 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00AG075196-03 |
| Project ID | NIH-11470695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults who have survived an ischemic stroke and can attend blood draws and periodic cognitive testing over several years.
✕Less likely to help
People without a history of ischemic stroke or those who already have advanced dementia are unlikely to be included or benefit directly from this project.
What this research studies
I would be followed after an ischemic stroke with regular cognitive checkups over time to track thinking and memory. Researchers will use routine blood tests and advanced protein (proteome) measurements to estimate biological aging and find protein patterns linked to brain resilience. They will combine those biomarkers with algorithms to see how they relate to when and if dementia starts after stroke. The goal is to link blood-based signals to real-world cognitive changes so future tests or treatments can be developed.
Why it matters
Potential benefit: If successful, this work could identify blood markers that predict dementia risk after stroke and point to targets to help protect thinking.
How similar studies have gone: Previous research has found links between biological aging measures or certain blood proteins and cognitive decline, but applying proteomics specifically to post-stroke cognitive resilience is relatively new.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Waziry, Reem — University of Florida
- Study coordinator: Waziry, Reem
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.