Using activity probes to improve microbiome therapies
Official title: Activity Probes to Guide Precision Microbiome Therapy
Funded at Weill Medical Coll of Cornell Univ · NIH-11180136 · Data updated 2026-11-12
This study is exploring how we can better understand and work with the tiny microbes in our bodies to improve health, especially for people dealing with obesity and cancer, by finding out which specific microbes can help us and creating personalized treatments just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,139,618 |
| NIH project number | 5R01AT013241-02 |
| Project ID | NIH-11180136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from obesity, cancer, or inflammatory diseases related to microbiome imbalances.
✕Less likely to help
Patients with stable microbiome profiles or those not affected by the conditions being studied may not benefit from this research.
What this research studies
This research investigates how to better understand and manipulate the human microbiome, which is crucial for health and disease management, particularly in conditions like obesity and cancer. By employing innovative activity-based probes, the study aims to directly measure the functions of microbial proteins, rather than relying on indirect indicators. This approach will help identify specific microbial taxa with beneficial functions, paving the way for tailored microbiome therapies that can be tested in clinical settings. Patients may benefit from more effective treatments that target their unique microbiome profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized microbiome-based therapies for various health conditions.
How similar studies have gone: Other research has shown promise in using microbiome profiling for therapeutic purposes, but this approach using activity-based probes is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Longman, Randy S — Weill Medical Coll of Cornell Univ
- Study coordinator: Longman, Randy S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.