ROMA:Women — comparing single vs multiple arterial grafts in women undergoing CABG
Official title: 1/2 Randomized comparison of the Outcomes of single vs Multiple Arterial grafts trial in Women (ROMA:Women)
Funded at Weill Medical Coll of Cornell Univ · NIH-11621860 · Data updated 2026-11-12
A women-focused clinical trial tests whether using more arterial grafts during heart bypass surgery improves outcomes and quality of life for women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $993,509 |
| NIH project number | 4UH3HL169564-02 |
| Project ID | NIH-11621860 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women aged 21 and older scheduled for CABG who are eligible for either single or multiple arterial graft strategies.
✕Less likely to help
Women who are not candidates for MAG or who have contraindications to specific arterial grafts may not benefit.
What this research studies
This program builds on an established cardiac surgery trial infrastructure to enroll 2,000 women undergoing CABG and randomize them to a single arterial graft or multiple arterial grafts. Participants will be followed over time to track major heart and brain events, as well as overall well-being and daily functioning. The study will use standard medical care across sites, with careful data collection on outcomes and quality of life to understand whether MAG offers real benefits for women. The goal is to generate clear evidence that can guide surgeons and patients in choosing graft strategies for female patients.
Why it matters
Potential benefit: If MAG proves beneficial, women undergoing CABG could experience fewer complications and better quality of life after surgery.
How similar studies have gone: Previous observational studies suggested MAG might help, but this trial aims to provide definitive evidence in women.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Gaudino, Mario Fl — Weill Medical Coll of Cornell Univ
- Study coordinator: Gaudino, Mario Fl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.