Destruction of noncoding RNAs in cancer
Official title: Destruction of noncoding RNAs
Funded at Weill Medical Coll of Cornell Univ · NIH-11638414 · Data updated 2026-11-12
This grant funds research to understand how noncoding RNAs are broken down, which could reveal new ways to influence cancer development and progression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $28,590 |
| NIH project number | 3R35GM147463-05S1 |
| Project ID | NIH-11638414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients in this grant as described (basic mechanistic study in cell systems).
✕Less likely to help
No direct patient participation or immediate clinical benefit described.
What this research studies
If funded, researchers will study how microRNAs and circular RNAs are degraded, including the role of Argonaute and TDMD in driving RNA destruction. The project builds on prior findings about enzymes that tag RNAs for destruction and aims to identify new RNAs that trigger this process. By mapping how noncoding RNAs are removed, the work could uncover targets for future cancer therapies and biomarkers. The research is conducted in a lab setting with cell lines and molecular techniques to dissect degradation pathways.
Why it matters
Potential benefit: A better understanding of noncoding RNA destruction could lead to new cancer treatment strategies and diagnostic markers.
How similar studies have gone: Previous work has identified TDMD mechanisms and TDMD effector proteins, indicating progress in this area, though much remains unknown.
Where this research is happening
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Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Kleaveland, Benjamin Monteverde — Weill Medical Coll of Cornell Univ
- Study coordinator: Kleaveland, Benjamin Monteverde
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.