NIH-funded research U01 cooperative agreement

Understanding the Genetics Behind IBD in South Florida

Official title: University of Miami IBD Genetic Research Center: Understanding the Genetic Architecture of IBD in the South Florida community

Funded at University of Miami School of Medicine · NIH-11601644 · Data updated 2026-11-12

This grant looks at how genes and the environment come together to influence inflammatory bowel disease in people living in South Florida.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniversity of Miami School of Medicine
NIH-funded
Lab location1 site (Coral Gables, United States)
Project startSeptember 30, 2022
Project endJune 30, 2027
Funding year2026
Award (this year)$148,427
NIH project number3U01DK134201-05S1
Project IDNIH-11601644 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are individuals with IBD (Crohn’s disease or ulcerative colitis) from the South Florida community who have consented to genetic and environmental studies.

Less likely to help

People without IBD or those not participating in genetic/environmental studies may not benefit directly.

What this research studies

The project uses genetic and environmental data from the South Florida community to uncover why IBD occurs and progresses. Researchers will analyze diverse patient samples, including genetic information and environmental factors, to map how these elements interact. The goal is to build a clearer picture of disease mechanisms that could lead to better prevention and treatment options for patients in this region.

Why it matters

Potential benefit: If successful, this work could lead to more personalized strategies for preventing and treating IBD in South Florida.

How similar studies have gone: Previous studies have shown that population-specific genetic analyses can reveal important disease associations and gene-environment interactions.

Where this research is happening

  • University of Miami School of Medicine
    Coral Gables, United States
    Active

Researchers

  • Principal investigator: Mccauley, Jacob L — University of Miami School of Medicine
  • Study coordinator: Mccauley, Jacob L

Related research

Other NIH-funded projects on the same topics.

  • Decoding how GAA repeats in FGF14 cause SCA27B

    This project looks at why a specific DNA repeat in the FGF14 gene leads to Spinocerebellar Ataxia 27B in adults.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11630855

  • Breathing therapy to help clear brain toxins in older adults who sleep poorly

    A small study will test a breathing-based therapy to boost brain toxin clearance in older adults with poor sleep patterns related to Alzheimer’s risk.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11617740

  • New retinal imaging to detect brain small vessel disease

    A fast, wide-field eye imaging method will measure how tiny retinal blood vessels rhythmically flow to help detect early brain small vessel disease.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11607100

  • MorpHiC Data Resource and Coordinating Center

    A national effort to build and share a comprehensive, high-quality catalogue of how human genes affect cell function when they’re turned off, using human cellular models.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11599438

  • MorPhiC data hub for gene function in human cells

    A data resource and coordinating center will organize and share information about how human genes affect cellular traits when knocked out, helping researchers understand gene functions.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11599437

  • Understanding Alzheimer's Genetic Risk in African and Admixed African-American People

    A study looks at genetic factors and biomarkers to understand why Alzheimer's disease affects African and admixed African-American communities differently.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11595891

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.