MorPhiC data hub for gene function in human cells
Official title: MorPhiC Data Resource and Administrative Coordinating Center
Funded at University of Miami School of Medicine · NIH-11599437 · Data updated 2026-11-12
A data resource and coordinating center will organize and share information about how human genes affect cellular traits when knocked out, helping researchers understand gene functions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 22, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $398,825 |
| NIH project number | 3U24HG012674-05S1 |
| Project ID | NIH-11599437 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant is a data/resource center and does not enroll patients directly; its outputs support studies that may involve patients in the future.
✕Less likely to help
No direct patient involvement in this center’s activities.
What this research studies
This grant funds a center that will build and manage a high-quality, easily usable data resource about how deleting human genes changes cellular behavior in disease-relevant cell models. It will ensure the data are findable, accessible, interoperable, and reusable, and will coordinate collaboration among multiple research teams. The center also supports administrative and data integration tasks to connect production, analysis, and validation efforts across the MorPhiC consortium. The overall aim is to accelerate discovery by providing researchers with a scalable catalog of cellular phenotypes linked to human genes.
Why it matters
Potential benefit: If successful, patients could benefit from faster translation of gene-function knowledge into disease mechanisms and potential targets.
How similar studies have gone: Similar large-scale phenotyping efforts in cell systems have generated valuable resources that advanced downstream research.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Schurer, Stephan C — University of Miami School of Medicine
- Study coordinator: Schurer, Stephan C
Related research
Other NIH-funded projects on the same topics.
-
Decoding how GAA repeats in FGF14 cause SCA27B
This project looks at why a specific DNA repeat in the FGF14 gene leads to Spinocerebellar Ataxia 27B in adults.
-
Breathing therapy to help clear brain toxins in older adults who sleep poorly
A small study will test a breathing-based therapy to boost brain toxin clearance in older adults with poor sleep patterns related to Alzheimer’s risk.
-
New retinal imaging to detect brain small vessel disease
A fast, wide-field eye imaging method will measure how tiny retinal blood vessels rhythmically flow to help detect early brain small vessel disease.
-
Understanding the Genetics Behind IBD in South Florida
This grant looks at how genes and the environment come together to influence inflammatory bowel disease in people living in South Florida.
-
MorpHiC Data Resource and Coordinating Center
A national effort to build and share a comprehensive, high-quality catalogue of how human genes affect cell function when they’re turned off, using human cellular models.
-
Understanding Alzheimer's Genetic Risk in African and Admixed African-American People
A study looks at genetic factors and biomarkers to understand why Alzheimer's disease affects African and admixed African-American communities differently.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.