Understanding the differences in naive CD8 T cells
Official title: Naive CD8 T cell functional heterogeneity
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11126434 · Data updated 2026-11-12
This study is looking at a special type of immune cell called naive CD8 T cells to find out how to make them work better against infections and vaccines, which could help improve treatments for diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 19, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $639,084 |
| NIH project number | 1R01AI184466-01A1 |
| Project ID | NIH-11126434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults and youth who are interested in improving immune responses to infections and vaccines.
✕Less likely to help
Patients with established immune deficiencies or those who are not able to mount an immune response may not benefit from this research.
What this research studies
This research investigates the diversity of naive CD8 T cells, which are crucial for the immune response. The team aims to identify specific subsets of these cells that can generate stronger responses to infections and vaccines. By studying how these naive T cells are formed and maintained, the researchers hope to develop strategies to enhance their effectiveness against diseases, including cancer. This could lead to improved vaccine responses and better protection against various pathogens.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and therapies that enhance the immune response in patients.
How similar studies have gone: Previous research has shown promising results in understanding T cell subsets, suggesting that this approach could yield significant insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Araki, Koichi — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Araki, Koichi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.