Understanding how the immune system affects mitochondrial diseases.
Official title: Mechanisms of Innate Immune Activation in Mitochondrial Disease Onset and Progression
Funded at Seattle Children's Hospital · NIH-11033840 · Data updated 2026-11-12
This study is looking at how the body's natural immune system affects the development and worsening of Leigh syndrome, a serious brain condition caused by genetic mitochondrial diseases, to find new ways to help treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $122,562 |
| NIH project number | 1K01AI187782-01 |
| Project ID | NIH-11033840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Leigh syndrome or other genetic mitochondrial diseases.
✕Less likely to help
Patients with mitochondrial diseases that do not involve immune system activation may not benefit from this research.
What this research studies
This research investigates the role of the innate immune system in the onset and progression of genetic mitochondrial diseases, particularly focusing on Leigh syndrome, a severe neurological condition. By studying how immune activation contributes to disease mechanisms, the research aims to uncover potential pathways for therapeutic intervention. The approach involves examining immune responses in animal models to better understand the relationship between mitochondrial dysfunction and immune activation. This could lead to new strategies for treating these complex diseases.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective therapies for patients suffering from genetic mitochondrial diseases.
How similar studies have gone: Previous research has shown promising results in understanding immune mechanisms in other diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Hanaford, Allison Rose — Seattle Children's Hospital
- Study coordinator: Hanaford, Allison Rose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.