Understanding how specific proteins influence blood cell development
Official title: The molecular mechanisms underlying context-specific Runx factor functions in directing hematopoietic cell identity
Funded at California Institute of Technology · NIH-10866170 · Data updated 2026-11-12
This study is looking at how certain proteins help make blood cells, especially T cells that fight infections and megakaryocytes that help with blood clotting, to better understand how these cells develop and what happens when things go wrong.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $95,315 |
| NIH project number | 1K99HL173688-01 |
| Project ID | NIH-10866170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or those interested in the mechanisms of blood cell development.
✕Less likely to help
Patients with conditions unrelated to blood cell development or those not affected by hematological issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that guide the development of blood cells, focusing on how certain proteins, known as transcription factors, regulate gene expression in different contexts. By studying the Runx transcription factors, the research aims to uncover their roles in the development of T cells and megakaryocytes, which are crucial for immune function and blood clotting, respectively. The project utilizes innovative cell culture techniques to mimic the early stages of blood cell development, allowing for a deeper understanding of these processes. This could lead to insights into both normal blood cell formation and conditions where this process goes awry.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood-related disorders, including leukemia and other hematological conditions.
How similar studies have gone: Previous research has shown promising results in understanding transcription factors' roles in cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Shin, Boyoung — California Institute of Technology
- Study coordinator: Shin, Boyoung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.