Understanding how specific proteins affect liver fat and bile acid processing
Official title: Dissecting the Role of Peroxisomal PEX Family Proteins in Hepatic Bile Acid and Lipid Metabolism
Funded at University of California Los Angeles · NIH-10823728 · Data updated 2026-11-12
This study is looking at how certain proteins in the liver help manage fat and bile acids, using different types of mice to see how these proteins affect liver health, which could help us understand liver diseases better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $44,129 |
| NIH project number | 1F31DK138752-01 |
| Project ID | NIH-10823728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders affecting liver function, particularly those over 21 years old.
✕Less likely to help
Patients with non-metabolic liver conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of PEX family proteins in the liver, which are crucial for managing fat and bile acid metabolism. By using genetically diverse mice, the study aims to uncover how these proteins influence lipid levels and overall liver function. The researchers will employ advanced techniques, including AAV-CRISPR, to disrupt specific proteins and observe the effects on liver metabolism. This could lead to a better understanding of liver health and related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver-related metabolic disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of organelles in lipid metabolism, suggesting potential for success in this area.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Smith, Emily Ann — University of California Los Angeles
- Study coordinator: Smith, Emily Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.