Understanding how specific neural cells contribute to gut function
Official title: Lineage and transcriptional analysis of sacral neural crest contribution to the enteric nervous system
Funded at California Institute of Technology · NIH-10888900 · Data updated 2026-11-12
This study is looking at how certain cells in the body help develop the nervous system in the gut, which is important for digestion, and it aims to uncover new information that could help people with conditions like Hirschsprung’s disease understand their situation better and find new treatment options.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HD111287-02 |
| Project ID | NIH-10888900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with congenital disorders of the enteric nervous system, such as Hirschsprung’s disease.
✕Less likely to help
Patients with acquired gastrointestinal disorders unrelated to congenital ENS development may not receive benefit from this research.
What this research studies
This research investigates the role of sacral neural crest cells in the development of the enteric nervous system (ENS), which is crucial for gut functions like digestion and peristalsis. By utilizing advanced molecular biology techniques, the study aims to identify unique gene signatures and the specific contributions of these cells to the ENS. The findings could provide insights into congenital disorders such as Hirschsprung’s disease, which results from improper ENS development. Patients may benefit from a better understanding of the underlying causes of their conditions and potential new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with congenital disorders affecting the enteric nervous system.
How similar studies have gone: Previous research has successfully explored the contributions of other neural crest populations to the enteric nervous system, but the specific focus on sacral neural crest cells is relatively novel.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Jacobs-Li, Jessica — California Institute of Technology
- Study coordinator: Jacobs-Li, Jessica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.