Understanding how specific nerve cells develop in the lower gastrointestinal tract
Contribution of the sacral neural crest to the peripheral nervous system of the post-umbilical gastrointestinal tract
This study is looking at how certain cells in your body help control gut function, especially in the lower part of your digestive system, to better understand conditions like aganglionic megacolon that can affect bowel health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11085277 on NIH RePORTER |
What this research studies
This research investigates the development of the enteric nervous system, which controls gut function, focusing on the sacral neural crest cells that contribute to this system. By examining how these cells migrate and differentiate into various types of neurons in the hindgut, the study aims to fill a significant knowledge gap regarding their role compared to vagal neural crest cells. The researchers will use advanced techniques, including a novel retrovirus labeling method, to track these cells over time and analyze their function. This work could provide insights into conditions like aganglionic megacolon, which affects bowel function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the enteric nervous system, such as aganglionic megacolon.
Not a fit: Patients with gastrointestinal disorders unrelated to nerve development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for gastrointestinal disorders related to nerve development.
How similar studies have performed: While the specific focus on sacral neural crest cells is less explored, similar studies on vagal neural crest cells have shown promising results in understanding enteric nervous system development.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Bronner, Marianne — California Institute of Technology
- Study coordinator: Bronner, Marianne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.