Understanding how small blood vessel issues affect thinking and memory.
Elucidating microvascular contributions to cognitive impairment at single-cell resolution
This study is looking at how tiny blood vessels in the brain can affect thinking and memory problems, like dementia, and aims to find new ways to help treat these issues by understanding the cells involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11057467 on NIH RePORTER |
What this research studies
This research investigates the role of small blood vessels in the brain and how their dysfunction contributes to cognitive impairment and dementia. By using advanced techniques to analyze brain tissue at a single-cell level, the study aims to uncover the molecular and cellular processes involved in conditions like cerebral small vessel disease (CSVD). The goal is to identify specific cell types and mechanisms that could lead to new therapeutic targets for treating dementia. Patients may benefit from insights that could inform future treatments and interventions for cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing cognitive decline or those diagnosed with dementia, particularly related to small vessel disease.
Not a fit: Patients with cognitive impairment due to non-vascular causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive impairment and dementia.
How similar studies have performed: Other research has shown promise in understanding vascular contributions to cognitive impairment, but this approach using single-cell analysis is relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Yang, Andrew Chris — J. David Gladstone Institutes
- Study coordinator: Yang, Andrew Chris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.