NIH-funded research Sbir 2 grant

Improving Neurological Health with Brain Training for Mild Cognitive Impairment (INHANCE-MCI)

Official title: Improving Neurological Health with Acetylcholine via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impairment (INHANCE-MCI)

Funded at Posit Science Corporation · NIH-11626504 · Data updated 2026-11-12

A computer-based brain training program is being tested to help people with mild cognitive impairment maintain thinking skills and daily functioning.

More Cognitive Impairment research and trials

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionPosit Science Corporation
NIH-funded
Lab location1 site (San Francisco, United States)
Project startSeptember 20, 2025
Project endMay 31, 2027
Funding year2026
Award (this year)$498,809
NIH project number3R44AG094520-02S1
Project IDNIH-11626504 on NIH RePORTER

Who could benefit from this research

Could help

Adults 21 years and older with mild cognitive impairment.

Less likely to help

Individuals without mild cognitive impairment or those not willing to engage with computer-based training may not benefit.

What this research studies

This project uses a computerized cognitive training program called INHANCE-MCI to target acetylcholine-related brain changes seen in mild cognitive impairment. It will be a double-blind, parallel-arm study where participants are randomly assigned to the intervention or an active control to measure cognitive performance, daily functioning, and brain chemistry. The study builds on prior SBIR and NIH-supported work and aims to understand how brain training can create lasting cognitive and functional gains. If successful, the program could become more widely available to help delay progression toward Alzheimer’s disease.

Why it matters

Potential benefit: If successful, patients may experience slower cognitive decline and better ability to perform everyday activities.

How similar studies have gone: Past studies show promise with computerized brain training, but results for cholinergic-related gains require further confirmation.

Where this research is happening

  • Posit Science Corporation
    San Francisco, United States
    Active

Researchers

  • Principal investigator: Attarha, Mouna — Posit Science Corporation
  • Study coordinator: Attarha, Mouna

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.