Understanding how sleep and daily rhythms affect heart and metabolic health
Official title: Mechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic health
Funded at Columbia University Health Sciences · NIH-11370292 · Data updated 2026-11-12
A study from Columbia aims to uncover how lack of sleep and misaligned daily schedules influence obesity, blood pressure, and heart disease risk, by looking at daily patterns of eating, activity, and sleep.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2021 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $952,560 |
| NIH project number | 5R35HL155670-06 |
| Project ID | NIH-11370292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who experience short or disturbed sleep and have or are at risk for obesity or cardiovascular disease may be eligible.
✕Less likely to help
Individuals with stable, healthy sleep patterns and no cardiometabolic risk may have less direct benefit.
What this research studies
This study investigates how different sleep patterns and misalignment with the day-night cycle impact energy balance and cardiovascular risk. Researchers will examine how longer, milder sleep restriction and circadian misalignment affect what people eat, how active they are, and how these behaviors relate to obesity and heart health. The goal is to map the biological pathways linking sleep and lifestyle choices to cardiometabolic outcomes in adults.
Why it matters
Potential benefit: If successful, the findings could inform strategies to improve sleep and daily routines to reduce obesity and cardiovascular risk.
How similar studies have gone: Prior work showed sleep restriction affects energy intake and brain reward networks, supporting potential benefits from longer, milder sleep interventions.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: St-Onge, Marie-Pierre — Columbia University Health Sciences
- Study coordinator: St-Onge, Marie-Pierre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.