Understanding how PDE1 affects heart function and calcium levels
Official title: Phosphodiesterase 1 (PDE1) Regulation of Myocardial Calcium and Function
Funded at Loyola University Chicago · NIH-11100812 · Data updated 2026-11-12
This study is looking at how a specific protein called PDE1 affects calcium levels and heart function, with the goal of finding new ways to help people with heart failure feel better and have stronger hearts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | January 22, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $86,915 |
| NIH project number | 3R01HL171586-02S1 |
| Project ID | NIH-11100812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with heart failure or related cardiac conditions who may benefit from improved heart function.
✕Less likely to help
Patients with non-cardiac conditions or those who do not have heart failure may not receive any benefit from this research.
What this research studies
This research investigates the role of phosphodiesterase 1 (PDE1) in regulating calcium levels and heart function. By examining how PDE1 interacts with G-protein coupled receptors (GPCRs) and affects cAMP signaling in heart cells, the study aims to identify potential therapeutic targets for improving cardiac function in heart failure. The research utilizes animal models to explore the effects of PDE1 inhibition on heart muscle cells, focusing on its ability to enhance contractility and reduce stress on the heart without causing arrhythmias.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce complications in patients with heart failure.
How similar studies have gone: Previous research has shown promising results with PDE inhibitors in improving heart function, suggesting that this approach may be effective.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Muller, Grace Kim — Loyola University Chicago
- Study coordinator: Muller, Grace Kim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.