Understanding how metabolism affects brain development in Down syndrome
Nuclear-Metabolic Interplay in Down syndrome
This study is looking at how the way our cells use energy affects brain development in people with Down syndrome, using special cells from humans and mice to find out how these processes might help improve brain function and support better outcomes for those with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11137615 on NIH RePORTER |
What this research studies
This research investigates the relationship between cellular metabolism and brain development in individuals with Down syndrome (DS). By using human stem cell and mouse models, the study aims to explore how metabolic processes influence the proliferation and differentiation of neural progenitor cells, which are crucial for proper brain function. The researchers will focus on three key metabolic pathways: glycolysis, lipid/cholesterol metabolism, and histone acetylation. The goal is to uncover the mechanisms that lead to neurodevelopmental challenges in DS and identify potential therapeutic strategies to improve outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Down syndrome, particularly those experiencing cognitive or developmental challenges.
Not a fit: Patients without Down syndrome or those who do not exhibit neurodevelopmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain development and cognitive function in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding metabolic influences on neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Meharena, Hiruy Sibhatu — University of California, San Diego
- Study coordinator: Meharena, Hiruy Sibhatu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.