Understanding how mechanical and molecular signals influence lung development
Official title: INTEGRATION OF MECHANICAL AND MOLECULAR CUES DURING DISTAL LUNG DEVELOPMENT
Funded at Mayo Clinic Rochester · NIH-11017026 · Data updated 2026-11-12
This study looks at how stretching and certain signals in the lungs help develop important cells that are needed for breathing and keeping the lungs healthy, with the hope of finding ways to help the lungs heal better in both babies and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $532,264 |
| NIH project number | 5R01HL171056-02 |
| Project ID | NIH-11017026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting lung function or those interested in lung health, particularly adults.
✕Less likely to help
Patients with acute lung injuries or conditions that do not involve alveolar cell differentiation may not benefit from this research.
What this research studies
This research investigates the role of mechanical stretch and molecular signals in the development of alveolar cells in the lungs. It focuses on how these factors influence the differentiation of two types of epithelial cells, AT1 and AT2, which are crucial for gas exchange and surfactant secretion. By examining how these signals are regulated during embryonic development and their potential reactivation in adulthood, the study aims to uncover mechanisms that could impact lung regeneration. The research employs advanced techniques to analyze cellular properties and signaling pathways involved in lung cell differentiation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing lung regeneration and treating respiratory diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular differentiation through mechanical and molecular cues, indicating potential for success in this area.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Brownfield, Douglas Glenn — Mayo Clinic Rochester
- Study coordinator: Brownfield, Douglas Glenn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.