Understanding how low brain glucose affects brain function
Official title: Brain glucose deficiency: mechanisms and modulation
Funded at Weill Medical Coll of Cornell Univ · NIH-11087259 · Data updated 2026-11-12
This study is looking at how problems with sugar processing in the brain might affect conditions like dementia and epilepsy, using mice to learn more about how these issues can change brain activity, with the hope of finding new ways to help people with these conditions feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,875,099 |
| NIH project number | 7RM1NS133593-02 |
| Project ID | NIH-11087259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurological disorders such as dementia or epilepsy, particularly those showing signs of glucose metabolism issues.
✕Less likely to help
Patients with neurological conditions unrelated to glucose metabolism may not benefit from this research.
What this research studies
This research investigates the role of glucose metabolism in brain function, particularly in conditions like dementia and epilepsy. It aims to understand how deficiencies in glucose transport can lead to changes in brain activity and excitability. By using a mouse model with glucose transporter deficiency, researchers will explore the relationship between metabolism and neural function, and how these processes can be observed and potentially modified in patients. The ultimate goal is to identify therapeutic strategies that can improve brain function in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance brain function in patients with neurological disorders linked to glucose metabolism.
How similar studies have gone: Previous research has shown promising results in understanding glucose metabolism's role in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Pascual, Juan M. — Weill Medical Coll of Cornell Univ
- Study coordinator: Pascual, Juan M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.