Understanding how immune interactions affect allergic inflammation
Official title: Neuroimmune interactions regulate development of allergic inflammation
Funded at Brigham and Women's Hospital · NIH-10992130 · Data updated 2026-11-12
This study is looking at how the immune system and allergies, like asthma and food allergies, work together, and it’s for anyone interested in understanding what causes these conditions and how we might find better treatments.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | November 28, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $584,623 |
| NIH project number | 5R37AI139536-07 |
| Project ID | NIH-10992130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from asthma, food allergies, or other allergic conditions, particularly those experiencing the atopic march.
✕Less likely to help
Patients with non-allergic respiratory or gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates the complex interactions between the immune system and allergic responses, particularly focusing on how certain immune signals can lead to conditions like asthma and food allergies. By analyzing specific receptors on sensory neurons in the lungs and gut, the study aims to uncover the mechanisms that drive allergic inflammation. The researchers utilize advanced techniques such as single-cell RNA sequencing to identify the roles of these receptors in regulating allergic reactions. This could provide insights into how allergies develop and progress, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that better manage or prevent allergic diseases.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in allergies, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Kuchroo, Vijay K. — Brigham and Women's Hospital
- Study coordinator: Kuchroo, Vijay K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.