Understanding how immune cells affect brain development in Down Syndrome
Microglial contribution to Down Syndrome Neuropathology
This study is looking at how certain immune cells in the brain, called microglia, might affect brain development in children and young adults with Down Syndrome, with the hope of finding new ways to help improve their thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11256941 on NIH RePORTER |
What this research studies
This research investigates the role of microglial cells, a type of immune cell in the brain, in the development of Down Syndrome (DS). It aims to understand how these cells contribute to neurodevelopmental deficits associated with DS, particularly in children and young adults. The researchers will use advanced techniques, including organoid microglia cocultures and a chimeric mouse model, to explore the interactions between microglia and brain development. By examining these cellular interactions, the study seeks to uncover potential therapeutic targets for improving cognitive outcomes in individuals with DS.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults diagnosed with Down Syndrome.
Not a fit: Patients without a diagnosis of Down Syndrome or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and overall quality of life for individuals with Down Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in other neurodevelopmental disorders, suggesting potential for success in this area as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Coufal, Nicole Gabriele — University of California, San Diego
- Study coordinator: Coufal, Nicole Gabriele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.