Personalized iTBS for Depression: Faster, Targeted Brain Stimulation

Who could benefit from this research

What this research studies

This project aims to tailor intermittent theta burst stimulation (iTBS) for people with treatment-resistant depression by adjusting stimulation frequency and brain target areas to match each patient’s own brain rhythms. By focusing on theta-gamma coupling and individualized parameters, the study seeks to improve remission rates while delivering treatment in a shorter daily session. Participants would undergo non-invasive brain stimulation with careful monitoring of mood and clinical outcomes to see if personalization offers added benefit. The research will be conducted at UC San Diego, led by Dr. Zafiris (Z. Daskalakis) and team, and will build on existing rTMS evidence in depression.

Why it matters

Where this research is happening

• University of California, San Diego
  La Jolla, United States Active

Researchers

• Principal investigator: Daskalakis, Zafiris J. — University of California, San Diego
• Study coordinator: Daskalakis, Zafiris J.

Related research

Other NIH-funded projects on the same topics.

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• Biotype-based Treatment Personalization for Resistant Late-Life Depression

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.