Understanding how hormonal changes during menopause affect mood and sleep.
Official title: Chronobiological Basis of Depression during the Menopause Transition
Funded at University of California, San Diego · NIH-11086837 · Data updated 2026-11-12
This study is looking at how changes in hormones during menopause can affect your sleep and mood, and it will test some light and sleep techniques to see if they can help you feel better and sleep more soundly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 9, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $668,102 |
| NIH project number | 5R01MH134120-02 |
| Project ID | NIH-11086837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women undergoing the menopause transition who are experiencing mood and sleep dysfunction.
✕Less likely to help
Patients who are not in the menopause transition or those without mood and sleep disturbances may not benefit from this research.
What this research studies
This research investigates how hormonal fluctuations during the menopause transition can disrupt circadian rhythms, leading to mood and sleep issues. The study will involve administering sleep and light interventions at specific times to help realign these rhythms and improve overall well-being. By measuring melatonin levels and other indicators, the researchers aim to determine the effectiveness of these interventions in alleviating depressive symptoms and enhancing sleep quality. Participants will be monitored to assess changes in mood and sleep patterns over time.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for women experiencing depression and sleep disturbances during menopause.
How similar studies have gone: Previous studies have shown promising results with similar interventions aimed at correcting circadian rhythm disruptions.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Parry, Barbara L — University of California, San Diego
- Study coordinator: Parry, Barbara L
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.