Understanding how HIV-1 assembles and interacts with host cells
Official title: Viral and Cellular Determinants of HIV-1 Assembly
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11090446 · Data updated 2026-11-12
This study is looking at how the HIV virus puts itself together inside our cells and is trying to find new ways to help treat HIV by understanding the role of certain proteins in this process, which could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 20, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $609,012 |
| NIH project number | 5R01AI186611-02 |
| Project ID | NIH-11090446 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are seeking innovative treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who are not responsive to antiretroviral therapies may not benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV-1 assembles infectious particles by examining the interactions between the virus and host cellular pathways. The team has identified specific adaptor proteins, such as Rab11-FIP1C, that are crucial for the trafficking and incorporation of HIV-1 envelope proteins into viral particles. By studying these interactions, the research aims to uncover new components of the recycling machinery that facilitate HIV-1 assembly, which could lead to novel therapeutic strategies. Patients may benefit from insights gained into how HIV-1 operates within the body, potentially informing future treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve treatment outcomes for patients living with HIV.
How similar studies have gone: Previous research has shown success in understanding viral assembly mechanisms, indicating that this approach has the potential for significant advancements.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Spearman, Paul W. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Spearman, Paul W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.