Understanding how hepatitis E virus leaves liver cells
Official title: Mechanism for hepatitis E virus exit from polarized hepatocytes
Funded at Research Inst Nationwide Children's Hosp · NIH-11012885 · Data updated 2026-11-12
This study is looking at how the hepatitis E virus leaves liver cells, focusing on a specific protein that helps with this process, to find better ways to prevent and treat hepatitis E, especially for people with weakened immune systems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | March 14, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $518,025 |
| NIH project number | 5R01AI174180-03 |
| Project ID | NIH-11012885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of hepatitis E infection, particularly those who are immunocompromised.
✕Less likely to help
Patients who have already been diagnosed with chronic hepatitis E or those without risk factors for infection may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the hepatitis E virus (HEV) exits polarized liver cells, which is crucial for understanding its infectious cycle. The study focuses on the role of a specific viral protein, ORF3, and its interaction with cellular machinery that facilitates the virus's release. By using human liver cell cultures and animal models, the research aims to uncover the complexities of HEV release, which could lead to new prevention and treatment strategies for hepatitis E. The findings could provide insights into the virus's behavior in immunocompromised individuals, who are at higher risk of severe disease.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective prevention and treatment options for hepatitis E, addressing a significant public health concern.
How similar studies have gone: Previous research has shown promise in understanding viral mechanisms in other infections, suggesting that this approach could yield valuable insights, although the specific focus on HEV is relatively novel.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Feng, Zongdi — Research Inst Nationwide Children's Hosp
- Study coordinator: Feng, Zongdi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.