Understanding how heart cells develop and maintain their identity
Mechanisms governing the differentiation and maintenance of atrial identity
This study is looking at how certain genes affect the development of heart cells, especially in babies, to understand why some newborns have heart defects and to find better ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11063165 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms that are crucial for the proper development of heart cells, particularly focusing on atrial cardiomyocytes. It aims to uncover how mutations in specific genes can lead to congenital heart defects, which are common in newborns and can result in serious complications like arrhythmias. By studying these mechanisms, the research seeks to provide insights into the causes of these defects and improve treatment strategies. The approach involves analyzing gene expression and the role of transcription factors in heart development.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns and children diagnosed with congenital heart defects, particularly those with atrial septal defects.
Not a fit: Patients with congenital heart defects that are not related to atrial development or those who are adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital heart defects and associated arrhythmias.
How similar studies have performed: Previous research has shown success in understanding genetic mechanisms related to congenital heart defects, making this approach promising.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Waxman, Joshua — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Waxman, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.