Understanding how genetic elements affect gut bacteria diversity
Official title: Diversity generation in the gastrointestinal microbiome
Funded at University of California Los Angeles · NIH-11005727 · Data updated 2026-11-12
This study is looking at how certain genetic elements in bacteria help them adapt and survive in our gut, specifically focusing on a type of bacteria called Bacteroides, to better understand how these changes affect the balance and health of our gut microbiome.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | January 3, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $170,492 |
| NIH project number | 5K08DK138316-02 |
| Project ID | NIH-11005727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in gut health and microbiome diversity.
✕Less likely to help
Patients who do not have gastrointestinal issues or are not interested in microbiome-related therapies may not benefit from this research.
What this research studies
This research investigates the role of Diversity Generating Retroelements (DGRs) in the gastrointestinal microbiome, focusing on how these genetic elements help bacteria adapt and thrive in their environment. By studying specific strains of Bacteroides, the research aims to uncover the mechanisms that control DGR activity and how these adaptations influence bacterial interactions and community stability. The approach includes both laboratory experiments and in vivo assessments to explore the functional roles of diversified proteins in the gut microbiome.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for manipulating gut bacteria to improve health outcomes.
How similar studies have gone: While the specific role of DGRs in the gut microbiome is largely unexplored, similar research has shown promise in understanding microbial adaptation and its implications for health.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Macadangdang, Benjamin — University of California Los Angeles
- Study coordinator: Macadangdang, Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.