NIH-funded research NIH-funded research

Mapping interactions in the human gut microbiome

Official title: Domesticating and Mapping Interactions of the Human Gastrointestinal Microbiome

Funded at Georgia Institute of Technology · NIH-11061015 · Data updated 2026-11-12

This study is all about figuring out how different bacteria in your gut work together and with your body, so we can find new ways to help improve gut health for everyone.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionGeorgia Institute of Technology
NIH-funded
Lab location1 site (Atlanta, United States)
Project startApril 1, 2024
Project endMarch 31, 2029
Funding year2025
Award (this year)$371,407
NIH project number5R35GM153457-02
Project IDNIH-11061015 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals with gastrointestinal issues or those interested in improving their gut health.

Less likely to help

Patients with stable gastrointestinal health and no interest in microbiome manipulation may not benefit from this research.

What this research studies

This research aims to create a toolkit for understanding how different bacteria in the gastrointestinal (GI) microbiome interact with each other and with human cells. By mapping these interactions, the researchers hope to find ways to manipulate the microbiome to improve health outcomes. The project will focus on domesticating more bacteria from the GI microbiome, which currently has very few domesticated species, to better understand their roles. This knowledge could lead to targeted therapies that promote a healthier gut microbiome.

Why it matters

Potential benefit: If successful, this research could lead to new treatments that enhance gut health and overall well-being by manipulating the microbiome.

How similar studies have gone: Previous research has shown promise in understanding the microbiome, but this approach of creating a universal toolkit for interaction mapping is relatively novel.

Where this research is happening

  • Georgia Institute of Technology
    Atlanta, United States
    Active

Researchers

  • Principal investigator: Wilson, Corey J. — Georgia Institute of Technology
  • Study coordinator: Wilson, Corey J.

Related research

Other NIH-funded projects on the same topics.

  • Mapping and controlling interactions in the human gut microbiome

    This project builds lab tools to map how gut bacteria interact with each other and with human cells, aiming to enable targeted changes that could help people with gut-related conditions.

    NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11312687

  • HIV reservoirs in the gut and how they reactivate when treatment stops

    This grant explores how HIV hides in the gut and why it can come back when ART is paused, with the goal of guiding better cure strategies.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11124594

  • Understanding how genetic elements affect gut bacteria diversity

    This study is looking at how certain genetic elements in bacteria help them adapt and survive in our gut, specifically focusing on a type of bacteria called Bacteroides, to better understand how these changes affect the balance and health of our gut microbiome.

    NIH research University of California Los Angeles · Los Angeles, United States · NIH-11005727

  • Gut microbes and blood signals in sepsis-related liver and kidney injury

    This study tests whether gut microbes and blood markers differ in adults with sepsis who develop liver or kidney injury, compared with healthy volunteers.

    Recruiting at 6 sites First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang and 5 other locations · NCT07735182

  • Plant-based beverage effects on the gut microbiome in healthy adults

    This study tests how drinking different plant-based beverages for two weeks affects the gut microbiome in healthy adults.

    Recruiting Lund University · Lund, Skåne County · NCT07730229

  • Inulin Prebiotic for Perimenopausal Women with Overweight or Obesity

    This study tests whether 2 weeks of inulin can affect gut and vaginal microbes, heart health, and muscle health in perimenopausal women who are overweight or obese, using a crossover design.

    Recruiting George Washington University · Washington D.C., District of Columbia · NCT07724522

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.