Understanding how gene expression is controlled during human development
Spatiotemporal regulation of epigenetic silencing by macromolecular interactions
This study is looking at how certain genes turn on and off during the early stages of human development, focusing on a special chemical change that helps control these genes, which is important for making sure our cells develop correctly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11141740 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate gene expression during the early development of the human body, focusing on how specific genes are activated or repressed. It examines the role of epigenetic modifications, particularly a specific type of histone methylation known as H3K27me3, which is crucial for controlling gene activity. By studying the interactions between proteins and nucleic acids, the research aims to uncover how these modifications are precisely regulated over time and space, which is essential for proper cell differentiation and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases associated with epigenetic changes.
Not a fit: Patients with conditions unrelated to epigenetic regulation or those who do not have genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating genetic diseases linked to epigenetic dysregulation.
How similar studies have performed: Other research has shown promising results in understanding epigenetic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Long, Yicheng — Weill Medical Coll of Cornell Univ
- Study coordinator: Long, Yicheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.