Understanding how gene expression is controlled during human development
Official title: Spatiotemporal regulation of epigenetic silencing by macromolecular interactions
Funded at Weill Medical Coll of Cornell Univ · NIH-11141740 · Data updated 2026-11-12
This study is looking at how certain genes turn on and off during the early stages of human development, focusing on a special chemical change that helps control these genes, which is important for making sure our cells develop correctly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $423,750 |
| NIH project number | 5R35GM155228-02 |
| Project ID | NIH-11141740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or diseases associated with epigenetic changes.
✕Less likely to help
Patients with conditions unrelated to epigenetic regulation or those who do not have genetic disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate gene expression during the early development of the human body, focusing on how specific genes are activated or repressed. It examines the role of epigenetic modifications, particularly a specific type of histone methylation known as H3K27me3, which is crucial for controlling gene activity. By studying the interactions between proteins and nucleic acids, the research aims to uncover how these modifications are precisely regulated over time and space, which is essential for proper cell differentiation and development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating genetic diseases linked to epigenetic dysregulation.
How similar studies have gone: Other research has shown promising results in understanding epigenetic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Long, Yicheng — Weill Medical Coll of Cornell Univ
- Study coordinator: Long, Yicheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.