Understanding how FGFR3 affects bone growth and development
FGFR3 Activities in the Control of Skeletal Growth
This study is looking at how a specific protein called FGFR3 affects bone growth, especially in people with achondroplasia, the most common type of dwarfism, to find new ways to help improve their growth and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11076818 on NIH RePORTER |
What this research studies
This research investigates the role of the fibroblast growth factor receptor 3 (FGFR3) in regulating skeletal growth, particularly in conditions like achondroplasia, which is the most common form of dwarfism. The study aims to explore the molecular pathways that FGFR3 influences in cartilage growth plates, where bone development occurs. By identifying how FGFR3 functions and its regulatory elements, researchers hope to discover new treatment strategies that could improve outcomes for individuals with achondroplasia. The research will utilize preclinical models to test these new approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with achondroplasia or other forms of chondrodysplasia.
Not a fit: Patients with skeletal growth disorders not related to FGFR3 or those without any genetic component affecting bone growth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for achondroplasia and related skeletal growth disorders.
How similar studies have performed: Previous research has shown promise in targeting FGFR3 pathways for treating achondroplasia, indicating that this approach has potential based on earlier findings.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lefebvre, Veronique M — Children's Hosp of Philadelphia
- Study coordinator: Lefebvre, Veronique M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.