Understanding how FGFR3 affects bone growth and development
Official title: FGFR3 Activities in the Control of Skeletal Growth
Funded at Children's Hosp of Philadelphia · NIH-11076818 · Data updated 2026-11-12
This study is looking at how a specific protein called FGFR3 affects bone growth, especially in people with achondroplasia, the most common type of dwarfism, to find new ways to help improve their growth and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $696,721 |
| NIH project number | 5R01AR083245-02 |
| Project ID | NIH-11076818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with achondroplasia or other forms of chondrodysplasia.
✕Less likely to help
Patients with skeletal growth disorders not related to FGFR3 or those without any genetic component affecting bone growth may not benefit from this research.
What this research studies
This research investigates the role of the fibroblast growth factor receptor 3 (FGFR3) in regulating skeletal growth, particularly in conditions like achondroplasia, which is the most common form of dwarfism. The study aims to explore the molecular pathways that FGFR3 influences in cartilage growth plates, where bone development occurs. By identifying how FGFR3 functions and its regulatory elements, researchers hope to discover new treatment strategies that could improve outcomes for individuals with achondroplasia. The research will utilize preclinical models to test these new approaches.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for achondroplasia and related skeletal growth disorders.
How similar studies have gone: Previous research has shown promise in targeting FGFR3 pathways for treating achondroplasia, indicating that this approach has potential based on earlier findings.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Lefebvre, Veronique M — Children's Hosp of Philadelphia
- Study coordinator: Lefebvre, Veronique M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.